4-((2-(1H-pyrazol-1-yl)phenyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine | 1174296-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-((2-(1H-pyrazol-1-yl)phenyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine
• 英文别名: 4-[2-(2-pyrazol-1-ylphenyl)ethynyl]-1H-pyrrolo[2,3-b]pyridine
• CAS: 1174296-76-4
• 化学式: C₁₈H₁₂N₄
• 分子量: 284.32
• InChiKey: TXCFJVYBLYEAES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROTEIN KINASE INHIBITORS AND USE THEREOF
  申请人：Askew Benny C.

  公开号：US20110282056A1

  公开（公告）日：2011-11-17

  Disclosed are compounds according to Formula I: wherein the variables are described herein.

  根据以下公式I披露了化合物：其中变量如本文所述。
• [EN] PROTEIN KINASE INHIBITORS AND USE THEREOF<br/>[FR] INHIBITEURS DE PROTÉINE KINASE ET LEUR UTILISATION
  申请人：MERCK SERONO SA

  公开号：WO2009094123A1

  公开（公告）日：2009-07-30

  Disclosed are compounds according to Formula I: wherein: W1 is CR8 or N, and W2 is -C-C=C-Ar; or W1 is -C-C≡C-Ar, and W2 is CR8 or N; Y is _s., -O-, -NH-, or -NHCH2-; X is N or N+-O';One aspect of the present invention is to provide novel compounds according to Formula l that are useful in the treatment of hyperproliferative diseases and inflammatory diseases. Specifically, the compounds of the invention are protein kinase inhibitors. As a result, this invention provides in a first aspect novel compounds according to Formula I, as well as pharmaceutically acceptable salts and pharmaceutically active derivatives thereof, that are useful for the treatment of a subject in need of inhibition of a protein kinase. Values and particular values for the variables in Formula I are provided in the following paragraphs.