2-[3-(3-hydroxyphenyl)propionylamino]-4-methylthiazole-5-carboxylic acid ethyl ester | 1400661-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[3-(3-hydroxyphenyl)propionylamino]-4-methylthiazole-5-carboxylic acid ethyl ester
• 英文别名: Ethyl 2-[3-(3-hydroxyphenyl)propanoylamino]-4-methyl-1,3-thiazole-5-carboxylate
• CAS: 1400661-10-0
• 化学式: C₁₆H₁₈N₂O₄S
• 分子量: 334.396
• InChiKey: GGQQFXUJMUCCNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• THIAZOLE AND THIOPHENE COMPOUNDS
  申请人：Gillespie Paul

  公开号：US20120238569A1

  公开（公告）日：2012-09-20

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

  本文提供的是式(I)的化合物及其药学上可接受的盐，其中取代基如规范中所披露的那样。这些化合物及含有它们的药物组合物对于治疗炎症性疾病和紊乱，例如哮喘和慢性阻塞性肺病，是有用的。
• US8404859B2
  申请人：——

  公开号：US8404859B2

  公开（公告）日：2013-03-26
• [EN] THIAZOLE AND THIOPHENE COMPOUNDS<br/>[FR] COMPOSÉS THIAZOLE ET THIOPHÈNE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012123471A1

  公开（公告）日：2012-09-20

  Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.