Cortisol 21-Benzoate | 74669-84-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Cortisol 21-Benzoate
• 英文别名: [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] benzoate
• CAS: 74669-84-4
• 化学式: C₂₈H₃₄O₆
• 分子量: 466.6
• InChiKey: XHRJCMVVIQIIGO-YGZHYJPASA-N

物化性质

• 熔点：
  194-199°C
• 溶解度：
  可溶于氯仿、可溶于二氯甲烷、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Ab externo intraocular shunt placement
  申请人：AqueSys, Inc.

  公开号：US10463537B2

  公开（公告）日：2019-11-05

  Placing an intraocular shunt ab externo into an eye can include inserting the shunt into the eye and either before and/or after insertion, ballooning a target outflow region of the eye to permit an outflow end of the shunt to be enveloped within the ballooned target outflow region. An injector docking device can optionally be used to guide insertion of the needle and shunt into the eye.

  将眼内分流器从外部插入眼球可包括将分流器插入眼球，并在插入之前和/或之后，将眼球的目标流出区气球化，使分流器的流出端被包裹在气球化的目标流出区内。可选择使用注射器对接装置，引导针头和分流器插入眼球。
• AB externo intraocular shunt placement
  申请人：AqueSys, Inc.

  公开号：US10470927B2

  公开（公告）日：2019-11-12

  Placing an intraocular shunt ab externo into an eye can include inserting the shunt into the eye and either before and/or after insertion, ballooning a target outflow region of the eye to permit an outflow end of the shunt to be enveloped within the ballooned target outflow region. An injector docking device can optionally be used to guide insertion of the needle and shunt into the eye.

  将眼内分流器从外部插入眼球可包括将分流器插入眼球，并在插入之前和/或之后，将眼球的目标流出区气球化，使分流器的流出端被包裹在气球化的目标流出区内。可选择使用注射器对接装置，引导针头和分流器插入眼球。
• Intraocular drug delivery
  申请人：AqueSys, Inc.

  公开号：US10667947B2

  公开（公告）日：2020-06-02

  An ab externo method of placing an intraocular implant into an eye can include advancing a needle, in which the implant is disposed, into the eye through conjunctiva and sclera of the eye. The implant can include a drug deliverable to the eye. The implant can thereafter be released to be anchored in the eye and elute the drug to the eye.

  将眼内植入物植入眼球的外用方法包括将放置植入物的针穿过眼结膜和巩膜刺入眼球。植入物可包括一种可输送到眼内的药物。此后，植入物可被释放以固定在眼球中，并将药物洗脱到眼球中。
• AB EXTERNO INTRAOCULAR SHUNT PLACEMENT
  申请人：Aquesys, Inc.

  公开号：EP3302381A1

  公开（公告）日：2018-04-11
• INTRAOCULAR DRUG DELIVERY
  申请人：Aquesys, Inc.

  公开号：EP3463228A1

  公开（公告）日：2019-04-10