(R)-2-methoxynaphthalene-1-sulfinamide | 1310105-69-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-2-methoxynaphthalene-1-sulfinamide
• CAS: 1310105-69-1
• 化学式: C₁₁H₁₁NO₂S
• 分子量: 221.28
• InChiKey: LTJGMXUFCBHURK-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 lithium hexamethyldisilazane 、 水 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 (R)-n-(2-羟基-2-甲基-1-苯基丙基)-4-甲基苯磺酰胺 、 (R)-2-methoxynaphthalene-1-sulfinamide
  参考文献：
  名称：

  Enantioselective Synthesis of Diverse Sulfinamides and Sulfinylferrocenes from Phenylglycine-Derived Chiral Sulfinyl Transfer Agent

  摘要：

  A new chiral sulfinyl, transfer auxiliary derived from readily available phenylglycine was developed. This auxiliary is utilized to synthesize a diverse array of alkyl- and arylsulfinamides and sulfinylferrocenes in high yields and excellent ee's. The desired products are produced in a one-pot sequence from the oxathiazolidine 2-oxide by two sequential nucleophilic additions that proceed in a stereospecific manner.

  DOI：

  10.1021/jo200715c

文献信息

• Enantioselective Synthesis of Diverse Sulfinamides and Sulfinylferrocenes from Phenylglycine-Derived Chiral Sulfinyl Transfer Agent
  作者：Zhengxu S. Han、Angelica M. Meyer、Yibo Xu、Yongda Zhang、Robert Busch、Sherry Shen、Nelu Grinberg、Bruce Z. Lu、Dhileep Krishnamurthy、Chris H. Senanayake

  DOI：10.1021/jo200715c

  日期：2011.7.1

  A new chiral sulfinyl, transfer auxiliary derived from readily available phenylglycine was developed. This auxiliary is utilized to synthesize a diverse array of alkyl- and arylsulfinamides and sulfinylferrocenes in high yields and excellent ee's. The desired products are produced in a one-pot sequence from the oxathiazolidine 2-oxide by two sequential nucleophilic additions that proceed in a stereospecific manner.