1-{4'-[1-methyl-5-(6-phenylpyridin-2-ylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic | 1380587-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-{4'-[1-methyl-5-(6-phenylpyridin-2-ylamino)-1H-pyrazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic
• 英文别名: 1-[4-[4-[1-Methyl-5-[(6-phenylpyridin-2-yl)amino]pyrazol-4-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
• CAS: 1380587-79-0
• 化学式: C₃₁H₂₆N₄O₂
• 分子量: 486.573
• InChiKey: YJFMWUSWGLTSOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  80
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND THEIR USE IN THE TREATMENT FIBROSIS
  申请人：Seiders Thomas Jon

  公开号：US20130253004A1

  公开（公告）日：2013-09-26

  Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

  本文描述了一些能够拮抗溶血磷脂酸受体的化合物。同时还描述了包括上述化合物的药物组合物和药物，在治疗LPA依赖性或LPA介导的病症或疾病方面，使用这些拮抗剂的方法，以及单独或与其他化合物组合使用的方法。
• LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF
  申请人：Amira Pharmaceuticals, Inc.

  公开号：EP2648714A2

  公开（公告）日：2013-10-16
• US9272990B2
  申请人：——

  公开号：US9272990B2

  公开（公告）日：2016-03-01
• [EN] LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE L'ACIDE LYSOPHOSPHATIDIQUE ET UTILISATIONS DE CEUX-CI
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2012078593A2

  公开（公告）日：2012-06-14

  Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.