5-(1-Methyl-2-oxo-1,2-dihydroquinolin-4-ylmethyl)thiazolidine-2,4-dione | 882008-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(1-Methyl-2-oxo-1,2-dihydroquinolin-4-ylmethyl)thiazolidine-2,4-dione
• 英文别名: 5-[(1-Methyl-2-oxoquinolin-4-yl)methyl]-1,3-thiazolidine-2,4-dione
• CAS: 882008-03-9
• 化学式: C₁₄H₁₂N₂O₃S
• 分子量: 288.327
• InChiKey: YZMSUFFPPWHNFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  91.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Carbostyril compound
  申请人：Otsuka Pharmaceutical Co., Limited

  公开号：EP2426128A1

  公开（公告）日：2012-03-07

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的氨基苯吡啶化合物 或其盐，其中 A 是直接键、低级亚烷基或低级亚烷基；X 是氧原子或硫原子；R4 和 R5 各代表一个氢原子；碳化吡啶骨架 3 和 4 位之间的键是单键或双键；R1 是氢原子等；R2 是氢原子等；R3 是氢原子等。本发明的羧基吡咯化合物或其盐可诱导产生 TFF，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。