5-(Bromomethyl)-4-isoxazolepropanoic acid | 479577-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(Bromomethyl)-4-isoxazolepropanoic acid
• 英文别名: 3-[5-(bromomethyl)-1,2-oxazol-4-yl]propanoic acid
• CAS: 479577-97-4
• 化学式: C₇H₈BrNO₃
• 分子量: 234.05
• InChiKey: UUROYBOIGCTEAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Oncology drug innovation
  申请人：Poulsen Skovgaard Hans

  公开号：US20050037445A1

  公开（公告）日：2005-02-17

  The present invention describes methods for identification of molecules expressed at a different level on the cell surface of cancer cells compared to non-malignant cells and methods of identification of cancer specific promoters to be used singly or in combination for delivery and expression of therapeutic genes for treatment of cancer. The invention furthermore describes targeting complexes targeted to cell surface molecules identified by the methods of the invention. In embodiments of the invention said targeting complexes comprise the promoters identified by the methods of the invention. In addition the invention describes methods of identifying binding partners for the cell surface molecules and the binding partners per se. Methods of treatment using the targeting complexes and uses of the targeting complexes for the preparation of a medicament arc also disclosed by the invention. Furthermore, the invention describes uses of the cell surface molecules or fragments thereof for preparation of vaccines.

  本发明描述了鉴定癌细胞与非恶性细胞相比在细胞表面以不同水平表达的分子的方法，以及鉴定癌症特异性启动子的方法，这些启动子可单独或组合使用，以传递和表达用于治疗癌症的治疗基因。本发明还进一步描述了针对本发明方法鉴定出的细胞表面分子的靶向复合物。在本发明的实施方案中，所述靶向复合物包括通过本发明方法鉴定的启动子。此外，本发明还描述了鉴定细胞表面分子结合伙伴和结合伙伴本身的方法。本发明还公开了使用靶向复合物的治疗方法和靶向复合物制备药物的用途。此外，本发明还描述了细胞表面分子或其片段在制备疫苗中的用途。
• METHODS FOR IDENTIFICATION OF CANCER CELL SURFACE MOLECULES AND CANCER SPECIFIC PROMOTERS, AND THERAPEUTIC USES THEREOF
  申请人：Buadbo APS

  公开号：EP1446501A2

  公开（公告）日：2004-08-18
• [EN] ONCOLOGY DRUG INNOVATION<br/>[FR] INNOVATION EN MATIERE DE THERAPIE ANTI-CANCEREUSE
  申请人：ODIN MEDICAL AS

  公开号：WO2003000928A2

  公开（公告）日：2003-01-03

  The present invention describes methods for identification of molecules expressed at a different level on the cell surface of cancer cells compared to non-malignant cells and methods of identification of cancer specific promoters to be used singly or in combination for delivery and expression of therapeutic genes for treatment of cancer. The invention furthermore describes targeting complexes targeted to cell surface molecules identified by the methods of the invention. In embodiments of the invention said targeting complexes comprise the promoters identified by the methods of the invention. In addition the invention describes methods of identifying binding partners for the cell surface molecules and the binding partners per se. Methods of treatment using the targeting complexes and uses of the targeting complexes for the preparation of a medicament are also disclosed by the invention. Furthermore, the invention describes uses of the cell surface molecules or fragments thereof for preparation of vaccines.