(E)-5-cyclohexylpent-3-enoic acid | 1646185-13-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-5-cyclohexylpent-3-enoic acid
• CAS: 1646185-13-8
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: MNDNCOONIINRFO-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  penta-3,4-dienoic acid ethyl ester 在 盐酸 、 copper(I) bromide dimethylsulfide complex 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 反应 75.0h， 生成 (E)-5-cyclohexylpent-3-enoic acid
  参考文献：
  名称：

  驯化用于直接碳金属化的羧基：关于使用阴离子，阴离子和酯烯醇盐的观察

  摘要：

  羧酸根阴离子，二价阴离子和酯烯醇盐可为定向的碳金属化反应提供同时的保护和活化。可以利用中间体的双碳负离子特性进一步控制CC键形成反应。

  DOI：

  10.1002/chem.201403294

文献信息

• Process for the preparation of an aldehyde
  申请人：DSM N.V.

  公开号：EP0839787A1

  公开（公告）日：1998-05-06

  Process for the preparation of an aldehyde through hydroformylation of an unsaturated organic compound in the presence of a catalyst system comprising rhodium or iridium and a multidentate organic phosphite ligand, wherein a monodentate phosphine is present. The process according to the invention can advantageously be carried out for the preparation of methyl-5-formylvalerate, which is an intermediate product in the preparation of ε-caprolactam or adipic acid, which are in turn raw materials for the preparation of nylon-6 and nylon-6,6, respectively.

  在由铑或铱和多价有机亚磷酸酯配体组成的催化剂体系存在下，通过不饱和有机化合物的氢甲酰化制备醛的工艺，其中存在单价膦。 5-甲酰基戊酸甲酯是制备ε-己内酰胺或己二酸的中间产物，而ε-己内酰胺或己二酸又分别是制备尼龙-6 和尼龙-6,6 的原料。
• Process for the continuous preparation of an alkyl 5-formylvalerate compound
  申请人：DSM N.V.

  公开号：EP0839794A1

  公开（公告）日：1998-05-06

  Process for the continuous preparation of an alkyl 5-formylvalerate by reacting an alkyl-3-pentenoate with carbon monoxide and hydrogen by hydroformylation using a catalyst system comprising rhodium or iridium and a multidentate organic phosphite ligand according to the general formula: in which n is 2-6, X is an n-valent organic bridging group and in which the end groups R1-R2 are monovalent aryl groups, wherein the process is carried out in the presence of an acid compound having a pKa between 1 and 12 measured in water at 18°C.

  根据通式，使用由铑或铱和多叉有机亚磷酸酯配位体组成的催化剂体系，通过加氢甲酰化使 3-戊烯酸烷基酯与一氧化碳和氢反应，从而连续制备 5-甲酰基戊酸烷基酯的工艺： 其中 n 为 2-6，X 为正价有机桥基，末端基团 R1-R2 为一价芳基。
• Process to separate a group 8-10 metal/phosphite ligand complex from an organic liquid
  申请人：DSM N.V.

  公开号：EP0895811A1

  公开（公告）日：1999-02-10

  Process to separate a group 8-10 metal/phosphite ligand complex from an organic liquid mixture, wherein the following steps are performed (1) contacting the organic liquid with a support having bonded thereto an organophosphine ligand and separating the organic mixture which is poor in group 8-10 metal/phosphite ligand complex, (2) contacting the thus obtained loaded support with an organic solvent and carbon monoxide and separating the thus obtained organic solvent rich in group 8-10 metal-phosphite ligand complex, and (3) reusing the support obtained in step (2) in step (1).

  从有机液体混合物中分离 8-10 族金属/亚磷酸配体络合物的工艺，其中包括以下步骤 (1) 将有机液体与接合了有机膦配体的载体接触，然后分离出有机混合物，该混合物中的 8-10 族金属/亚磷酸配体络合物含量较低、 (2) 将由此获得的负载支撑体与有机溶剂和一氧化碳接触，分离由此获得的富含 8-10 族金属-亚磷酸配体络合物的有机溶剂，以及 (3) 在步骤（1）中重复使用在步骤（2）中获得的支撑物。
• Process to separate a rhodium/phosphite ligand complex and free phosphite ligand complex from a hydroformylation mixture
  申请人：DSM N.V.

  公开号：EP1103303A1

  公开（公告）日：2001-05-30

  Process to separate a rhodium/phosphite ligand complex and free phosphite ligand from a hydroformylation mixture also containing high boiling hydroformylation compounds by contacting said mixture with a polymeric membrane, wherein said mixture is diluted with at least one diluent compound having a solubility parameter such that the absolute difference in relation to the solubiltity parameter of the membrane lies between 0 and 400kJ/m3 and the ratio of the molar volume of the phosphite ligand and said diluent compound is ≥ 1.5, to such an extent that the amount of high boiling compounds in said mixture is ≤ 50 wt.% and/or the amount of compounds with a molecular weight of between x ± 200 is ≤ 20 wt.% whereby x is the cut-off of the membrane (g/mole) (relative to the total amount of the mixture).

  将铑/亚磷酸配体络合物和游离亚磷酸配体从还含有高沸点加氢甲酰化合物的加氢甲酰化混合物中分离出来的工艺，方法是将所述混合物与聚合物膜接触，其中所述混合物用至少一种稀释剂化合物稀释，稀释剂化合物的溶解度参数与膜的溶解度参数的绝对差值介于0和400kJ/m3之间，且亚磷酸配体与所述稀释剂化合物的摩尔体积之比≥1.5，从而使所述混合物中高沸点化合物的含量≤ 50 重量％和/或分子量在 x ± 200 之间的化合物的含量≤ 20 重量％，其中 x 为膜的截止值（克/摩尔）（相对于混合物的总量）。
• PROCESS TO PREPARE A TERMINAL ALDEHYDE
  申请人：DSM N.V.

  公开号：EP0888274A1

  公开（公告）日：1999-01-07