1,5-Dihydro-2H-pyrido[3,2-b]indol-2-one | 63367-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,5-Dihydro-2H-pyrido[3,2-b]indol-2-one
• 英文别名: 1,5-dihydropyrido[3,2-b]indol-2-one
• CAS: 63367-91-9
• 化学式: C₁₁H₈N₂O
• 分子量: 184.19
• InChiKey: QKFBMKOHIPTZSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] P2X4 RECEPTOR MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULATEURS DU RÉCEPTEUR P2X4
  申请人：SUNOVION PHARMACEUTICALS INC

  公开号：WO2015088564A1

  公开（公告）日：2015-06-18

  Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.

  本文提供了P2X4受体调节化合物，其合成方法，包含这些化合物的药物组合物，以及它们的使用方法。本文提供的化合物可用于治疗、预防和/或管理各种疾病，包括但不限于慢性疼痛、神经病变、炎症性疾病和中枢神经系统疾病。
• [EN] 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES<br/>[FR] 1,5-DIHYDROPYRIDO[3,2-B]INDOL-2-ONES SUBSTITUEES EN POSITION 4
  申请人：TIBOTEC PHARM LTD

  公开号：WO2005111044A1

  公开（公告）日：2005-11-24

  4-substituted 1,5-dihydro-pyrido[3,2-b]indol-2-ones of formula (I): the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein n is 1, 2 or 3; R1 is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxymethanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; X is NR 2, O, S, SO, SO2; R2 is hydrogen, C 1-10alkyl, C2-10alkenyl, C 3-7cycloalkyl, which are optionally substituted; R2 is aryl substituted with -COOR4 ; or R2 is: (b-1); (b-2); -CpH2p-CH(OR14 )-CqH 2q-R15(b-3); -CH2-CH2-(O-CH2-CH2)m-OR14 (b-4); -CH2-CH2-(O-CH2-CH2)m-NR5aR5b(b-5); -a1=a2-a3=a4- is -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N-; wherein hydrogen atoms in (c-1) - (c-5) may be replaced by certain radicals; R3 is obtionally substituted phenyl or a monocyclic or bicyclic aromatic heterocyclic ring system that can be substituted; R21 is halo, hydroxy, amino, carboxyl, C1-6alkyl, C3-7cycloalkyl, arylC1-6alkyl, formyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonylo xy, -C(=O)-NR13R14; C1-6alkyloxy, arylC1-6alkyloxy, polyhaloC1-6alkyloxy, amino, mono or di(C1-6alkyl)amino, formylamino, C1-6alkylcarbonylamino, C1-6alkylsulfo nylamino, mercapto, C1-6alkylthio, arylthio, aryloxy, arylC1-6alkylthio, C1-6alkylsulfynyl, C1-6alkylsulfo nyl, aryl, arylamino, Het1, Het2.

  公式（I）的4-取代1,5-二氢吡啶并[3,2-b]吲哚-2-酮：其N-氧化物，盐，立体异构体形式，消旋混合物，前药，酯和代谢物，其中n为1、2或3；R1为氢，氰基，卤素，取代羰基，甲基亚胺基，N-羟甲基亚胺基，单或双(C1-4烷基)甲基亚胺基，Het1或Het2；X为NR 2，O，S，SO，SO2；R2为氢，C1-10烷基，C2-10烯基，C3-7环烷基，可选择地取代；R2为取代为-COOR4的芳基；或R2为：(b-1)；(b-2)；-CpH2p-CH(OR14)-CqH2q-R15(b-3)；-CH2-CH2-(O-CH2-CH2)m-OR14(b-4)；-CH2-CH2-(O-CH2-CH2)m-NR5aR5b(b-5)；-a1=a2-a3=a4-为-CH=CH-CH=CH-；-N=CH-CH=CH-；-CH=N-CH=CH-；-CH=CH-N=CH-；-CH=CH-CH=N-；其中(c-1)-(c-5)中的氢原子可被某些基团取代；R3为可选择地取代的苯基或可以被取代的单环或双环芳香杂环系统；R21为卤素，羟基，氨基，羧基，C1-6烷基，C3-7环烷基，芳基C1-6烷基，甲酰基，C1-6烷基羰基，C1-6烷氧羰基，C1-6烷基羰氧基，-C(=O)-NR13R14；C1-6烷氧基，芳基C1-6烷氧基，多卤C1-6烷氧基，氨基，单或双(C1-6烷基)氨基，甲酰氨基，C1-6烷基羰胺基，C1-6烷基磺酰氨基，巯基，C1-6烷基硫基，芳基硫基，芳氧基，芳基C1-6烷基硫基，C1-6烷基烯基基，C1-6烷基磺基，芳基，芳胺基，Het1，Het2。
• 4-SUBSTITUTED 1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES
  申请人：Tibotec Pharmaceuticals Ltd.

  公开号：EP1751165A1

  公开（公告）日：2007-02-14