4-[4-(Furan-3-yl)imidazol-1-yl]butan-1-amine | 1214756-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[4-(Furan-3-yl)imidazol-1-yl]butan-1-amine
• CAS: 1214756-08-7
• 化学式: C₁₁H₁₅N₃O
• 分子量: 205.26
• InChiKey: UOJAXIDDNRPFSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[4-(Furan-3-yl)imidazol-1-yl]butan-1-amine 、 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens

  摘要：

  A novel series of acylides 4 were designed to overcome antibacterial resistance and evaluated for in vitro and in vivo activity. This series of acylides was designed from clarithromycin by changing the substitution on the desosamine nitrogen, followed by conversion to 3-O-acyl and 11,12-carbamate. These compounds showed significantly potent antibacterial activity against not only Gram-positive pathogens, including macrolide-lincosamide-streptogramin B (MLSB)-resistant and efflux-resistant strains, but also Gram-negative pathogens such as Haemophilus influenzae. These acylides also showed better activity against telithromycin resistant Streptococcus pneumoniae strains. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.101

文献信息

• KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：RANBAXY LABORATORIES, LTD.

  公开号：EP1794171A2

  公开（公告）日：2007-06-13
• [EN] KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES DE CETOLIDES AGENTS ANTIBACTERIENS
  申请人：DAS BISWAJIT

  公开号：WO2006080954A1

  公开（公告）日：2006-08-03

  [EN] The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing siuch ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.
  [FR] L'invention porte sur des dérivés de cétolides, utilisables comme agents antibactériens et en particulier pour traiter ou prévenir des états provoquée ou aggravé par des bactéries Gram-positives Gram-négatives ou anaérobies, et plus particulièrement par exemple par les Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bactéroides, Corynéebacterium, Bacillus or Enterobactericeae. . L'invention porte également sur les procédés de préparation de ces dérivés, sur des préparations pharmaceutiques les contenant, et sur des méthodes de traitement d'infections bactériennes.
• Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens
  作者：Rajesh Kumar、Sujata Rathy、Atul K. Hajare、Yogesh B. Surase、Jyoti Dullu、Jitendra S. Jadhav、R. Venkataramanan、Anjan Chakrabarti、Manisha Pandya、Pragya Bhateja、G. Ramkumar、Biswajit Das

  DOI：10.1016/j.bmcl.2011.10.101

  日期：2012.1

  A novel series of acylides 4 were designed to overcome antibacterial resistance and evaluated for in vitro and in vivo activity. This series of acylides was designed from clarithromycin by changing the substitution on the desosamine nitrogen, followed by conversion to 3-O-acyl and 11,12-carbamate. These compounds showed significantly potent antibacterial activity against not only Gram-positive pathogens, including macrolide-lincosamide-streptogramin B (MLSB)-resistant and efflux-resistant strains, but also Gram-negative pathogens such as Haemophilus influenzae. These acylides also showed better activity against telithromycin resistant Streptococcus pneumoniae strains. (C) 2011 Elsevier Ltd. All rights reserved.