3-(4-fluorophenyl)-1-[1-(4-fluorophenyl)ethyl]-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid ethylamide | 1427265-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(4-fluorophenyl)-1-[1-(4-fluorophenyl)ethyl]-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid ethylamide
• 英文别名: N-ethyl-3-(4-fluorophenyl)-1-[(1S)-1-(4-fluorophenyl)ethyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
• CAS: 1427265-27-7
• 化学式: C₂₃H₂₄F₂N₄O
• 分子量: 410.467
• InChiKey: OQTUMNSPABDCGO-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted 4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridines, Their Use as Medicament, and Pharmaceutical Preparations Comprising Them
  申请人：SANOFI

  公开号：US20140330009A1

  公开（公告）日：2014-11-06

  The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.

  这项发明涉及到式(I)的取代4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶类化合物，它们作为药物的用途，以及包含它们的药物制剂。式(I)的化合物作用于TASK-1钾通道。这些化合物特别适用于治疗或预防心房心律失常，例如心房颤动（AF）或心房扑动。
• SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM
  申请人：SANOFI

  公开号：EP2755973B1

  公开（公告）日：2015-11-04
• US9127001B2
  申请人：——

  公开号：US9127001B2

  公开（公告）日：2015-09-08