5-methyl-N-(5-{[(4-methyl-1,3-thiazol-2-yl)carbonyl]amino}bicyclo[3.2.1]oct-1-yl)pyrazine-carboxamide | 1383972-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-methyl-N-(5-{[(4-methyl-1,3-thiazol-2-yl)carbonyl]amino}bicyclo[3.2.1]oct-1-yl)pyrazine-carboxamide
• 英文别名: 4-methyl-N-[5-[(5-methylpyrazine-2-carbonyl)amino]-1-bicyclo[3.2.1]octanyl]-1,3-thiazole-2-carboxamide
• CAS: 1383972-18-6
• 化学式: C₁₉H₂₃N₅O₂S
• 分子量: 385.49
• InChiKey: DQLSDHZAVUMHCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME
  申请人：Li Guiying

  公开号：US20120190686A1

  公开（公告）日：2012-07-26

  The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R 1 and R 2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.

  本发明提供了式(I)的双环[3.2.1]辛基酰胺衍生物，其中L、R1和R2如本文所定义，或其药学上可接受的盐；以及使用它们的药物组合物和方法。
• BICYCLO[3.2.1.]OCTYL AMIDE DERIVATIVES AND USES OF SAME
  申请人：H. Lundbeck A/S

  公开号：US20150057289A1

  公开（公告）日：2015-02-26

  The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R 1 and R 2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.

  本发明提供一种式为(I)的双环[3.2.1]辛基酰胺衍生物：其中，L、R1和R2如本文所定义，或其药学上可接受的盐；以及使用它们的药物组合物和方法。
• BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AS ALLOSTERIC MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLU5 OR MGLUR5) FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS
  申请人：H. Lundbeck A/S

  公开号：EP3263566A1

  公开（公告）日：2018-01-03

  The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R1 and R2 are as defined herein, as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders, such as e.g. mood disorders, anxiety, schizophrenia, Alzheimer's disease, Parkinson's disease and multiple sclerosis.

  本发明提供了式 (I) 的双环[3.2.1]辛基酰胺衍生物： 其中 L、R1 和 R2 如本文所定义，作为代谢谷氨酸受体 5（mGlu5 或 mGluR5）的异位调节剂，用于治疗中枢神经系统（CNS）疾病，例如情绪障碍、焦虑、精神分裂症、阿尔茨海默病、帕金森病和多发性硬化症。
• Bicyclo[3.2.1]octyl amide derivatives as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders
  申请人：H. Lundbeck A/S

  公开号：EP2654422B1

  公开（公告）日：2017-08-02
• Bicyclo[3.2.1]Octyl Amide Derivatives and Uses of Same
  申请人：H. Lundbeck A/S

  公开号：US20170217950A1

  公开（公告）日：2017-08-03

  The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R 1 and R 2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.