9-(4-chlorobenzoyl)-7-(3-chlorophenyl)-2,3-dihydro-1H,5H-benzo[ij]quinolizin-5-one | 213389-74-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 9-(4-chlorobenzoyl)-7-(3-chlorophenyl)-2,3-dihydro-1H,5H-benzo[ij]quinolizin-5-one
• 英文别名: 7-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one
• CAS: 213389-74-3
• 化学式: C₂₅H₁₇Cl₂NO₂
• 分子量: 434.321
• InChiKey: WRQKKNNHPUUJEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-(4-chlorobenzoyl)-7-(3-chlorophenyl)-2,3-dihydro-1H,5H-benzo[ij]quinolizin-5-one 在 ammonium hydroxide 、 正丁基锂 、 氯化亚砜 、 三乙基氯硅烷 作用下， 以 四氢呋喃 为溶剂， 生成 7-[Amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one
  参考文献：
  名称：

  5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

  摘要：

  The evaluation of structure activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00180-x
• 作为产物：
  描述：

  3-chlorocinnamoyl chloride 在 溴 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 9-(4-chlorobenzoyl)-7-(3-chlorophenyl)-2,3-dihydro-1H,5H-benzo[ij]quinolizin-5-one
  参考文献：
  名称：

  5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

  摘要：

  The evaluation of structure activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00180-x

文献信息

• 1,8-Annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
  申请人：Angibaud Rene Patrick

  公开号：US20050176702A1

  公开（公告）日：2005-08-11

  This invention comprises the novel compounds of formula (I) wherein r, s, A, X, Y 1 , Y 2 , R 1 , R 2 , R 3 , and R 4 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  本发明涉及一种具有法尼醇转移酶抑制活性的新型化合物，其化学式为(I)，其中r、s、A、X、Y1、Y2、R1、R2、R3和R4具有定义的含义。本发明还涉及其制备方法、含有它们的组合物以及它们作为药物的用途。
• 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
  申请人：Janssen Pharmaceutica, N.V.

  公开号：US07408063B2

  公开（公告）日：2008-08-05

  This invention comprises the novel compounds of formula (I) wherein r, s, A, X, Y1, Y2, R1, R2, R3, and R4 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

  这项发明包括式(I)的新化合物，其中r、s、A、X、Y1、Y2、R1、R2、R3和R4具有定义的含义，具有法尼酰转移酶抑制活性；它们的制备、含有它们的组合物及其作为药物的用途。
• 1,8-ANNELATED QUINOLINE DERIVATIVES SUBSTITUTED WITH CARBON-LINKED TRIAZOLES AS FARNESYL TRANSFERASE INHIBITORS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1458720A1

  公开（公告）日：2004-09-22
• US7408063B2
  申请人：——

  公开号：US7408063B2

  公开（公告）日：2008-08-05
• [EN] 1,8-ANNELATED QUINOLINE DERIVATIVES SUBSTITUTED WITH CARBON-LINKED TRIAZOLES AS FARNESYL TRANSFERASE INHIBITORS<br/>[FR] UTILISATION DE DERIVES DE QUINOLINE 1,8-ANNELES SUBSTITUES AVEC DES TRIAZOLES LIES PAR LE CARBONE EN TANT QU'INHIBITEURS DE FARNESYL TRANSFERASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2003051880A1

  公开（公告）日：2003-06-26

  This invention comprises the novel compounds of formula (I) wherein r, s, A, X, Y1, Y2, R1, R2, R3, and R4 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.