2-methyl-2-{4-[2-(4-trifluoromethylphenyl)-2H-indazol-7-ylmethoxy]phenylsulfanyl}propionic acid | 860006-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methyl-2-{4-[2-(4-trifluoromethylphenyl)-2H-indazol-7-ylmethoxy]phenylsulfanyl}propionic acid
• 英文别名: 2-Methyl-2-[4-[[2-[4-(trifluoromethyl)phenyl]indazol-7-yl]methoxy]phenyl]sulfanylpropanoic acid
• CAS: 860006-99-1
• 化学式: C₂₅H₂₁F₃N₂O₃S
• 分子量: 486.515
• InChiKey: VXGUKZZEEJIOLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  89.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Bicyclic derivatives as ppar modulators
  申请人：Conner Eugene Scott

  公开号：US20070106081A1

  公开（公告）日：2007-05-10

  The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C 0 -C 8 alkyl and C 1-4 -heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O) 2 and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.
• US7544707B2
  申请人：——

  公开号：US7544707B2

  公开（公告）日：2009-06-09