1,4-dimethoxy-2,5-xylenyldiazide | 1408071-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,4-dimethoxy-2,5-xylenyldiazide
• 英文别名: 1,4-bis(azidomethyl)-2,5-dimethoxybenzene；1,3-bis(azidomethyl)dimethoxybenzene
• CAS: 1408071-68-0
• 化学式: C₁₀H₁₂N₆O₂
• 分子量: 248.244
• InChiKey: VHEGFCHNGZMDOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,4-dimethoxy-2,5-xylenyldiazide 、 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 10.0h， 以55%的产率得到C₃₅H₃₁N₉O₄S₂
  参考文献：
  名称：

  三唑基大环酰胺的点击化学合成及其抗炎活性

  摘要：

  摘要 通过点击化学合成了具有酰胺基团作为环内官能团的三唑基大环酰胺 1-12。与参考药物泼尼松龙相比，基于三唑的大环酰胺 1-12 即使在低浓度 (50 µg/mL) 下也显示出良好的抗炎活性。基于 BINOL 的手性大环酰胺和基于吡啶的大环酰胺显示出比​​其他合成的大环酰胺更好的抗炎活性。图形概要

  DOI：

  10.1080/00397911.2016.1254800

文献信息

• 1,2,3-Triazole Ferrocenyldendrimers Through Click Chemistry Approach and their Optical and Electrochemical Properties
  作者：Perumal Rajakumar、Ramasamy Anandhan、Ayyavoo Kannan

  DOI：10.1071/ch12166

  日期：——

  Novel ferrocenyl dendrimers with ferrocene as a surface group and with triazole as a bridging unit have been synthesised through click chemistry. The increasing numbers of triazole and ferrocenyl units at the antenna increase the light absorbing ability. The electrochemical behaviour changes with increasing ferrocenyl and triazole units.

  通过点击化学合成了具有二茂铁作为表面基团和三唑作为桥连单元的新型二茂铁基树枝状聚合物。天线上三唑和二茂铁基单元数量的增加增加了光吸收能力。电化学行为随二茂铁基和三唑单元的增加而变化。
• Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors
  作者：Fei Yu、Yiyun Peng、Qi Wang、Yongying Shi、Longlong Si、Han Wang、Yongxiang Zheng、Emily Lee、Sulong Xiao、Maorong Yu、Yingbo Li、Chuanling Zhang、Hengli Tang、Chunguang Wang、Lihe Zhang、Demin Zhou

  DOI：10.1016/j.ejmech.2014.03.017

  日期：2014.4

  The development of entry inhibitors is an emerging approach to the prevention and reduction of HCV infection. Starting from echinocystic acid (EA), a mu M HCV entry inhibitor, we have developed a series of bivalent oleanane-type triterpenes which, upon optimization of the length, rigidity and hydrophobicity of the linker, exert dramatically potent enhancement of inhibition with IC50 values extending into the nM level. This study establishes the importance of triterpene natural products as new leads in the development of potential HCV entry inhibitors. (c) 2014 Elsevier Masson SAS. All rights reserved.
• Synthesis and photophysical, antibacterial studies of some novel molecular tweezers
  作者：Sivasamy Selvarani、Ayyavu Thirunarayanan、Perumal Rajakumar

  DOI：10.1080/10610278.2015.1089998

  日期：2016.4.2

  Zeroth and first generation dendritic wedges with thiophene amide as surface group and 1, 2, 3-triazole as bridging unit which can function as molecular tweezers are synthesised by both convergent and divergent approaches. All the synthesised dendritic wedges displayed the absorbance band between 256 and 294nm and fluorescence maximum between 357 and 528nm supporting their self complementary property. Dendritic wedge 5 showed better antibacterial activity than other dendritic wedges in the assay against the human pathogens viz Staphylococcus aureus, Escherichia coli, Bacillus cereus and Klebsiella pneumonia and the dentritic wedge 5 was also effective in the computational molecular docking studies.