2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-chloro-phenyl)-3H-imidazo[4,5-b]pyridine | 1332876-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-chloro-phenyl)-3H-imidazo[4,5-b]pyridine
• 英文别名: 2-(5-tert-butyl-4-chloro-2-methylpyrazol-3-yl)-6-(2-chlorophenyl)-1H-imidazo[4,5-b]pyridine
• CAS: 1332876-72-8
• 化学式: C₂₀H₁₉Cl₂N₅
• 分子量: 400.31
• InChiKey: WKMUSDYCKJVOCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2542552A1

  公开（公告）日：2013-01-09
• [EN] SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS D'IMIDAZOLE AZA-BICYCLIQUES SUBSTITUÉS UTILES COMME MODULATEURS DES RÉCEPTEURS TRPM8
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011109587A1

  公开（公告）日：2011-09-09

  The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.