2,5-bis-[2-(5-amidino-pyridyl)]thiophene | 1143621-41-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,5-bis-[2-(5-amidino-pyridyl)]thiophene
• 英文别名: 6-[5-(5-Carbamimidoylpyridin-2-yl)thiophen-2-yl]pyridine-3-carboximidamide
• CAS: 1143621-41-3
• 化学式: C₁₆H₁₄N₆S
• 分子量: 322.393
• InChiKey: KMPJUMXTLPNRDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• 2,5-DIARYL SELENOPHENE COMPOUNDS, AZA 2,5-DIARYL THIOPHENE COMPOUNDS, AND THEIR PRODRUGS AS ANTIPROTOZOAL AGENTS
  申请人：Tidwell Richard R.

  公开号：US20100331368A1

  公开（公告）日：2010-12-30

  Novel dicationic 2,5-diaryl selenophene compounds are described. Also described are novel aza analogues of dicationic 2,5-diaryl thiophenes. The presently disclosed dicationic compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum , and/or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic compounds display good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.

  本文描述了新型二阳离子2,5-二芳基硒吡咯烷化合物。同时，还描述了新型二阳离子2,5-二芳基噻吩的氮杂环类似物。目前披露的二阳离子化合物在体外对Trypanosoma brucei rhodesiense、Plasmodium falciparum和/或Leishmania donovani表现出与Pentamidine和Furamidine相当的活性。其中一些新型二阳离子化合物在Trypanosoma brucei rhodesiense感染的小鼠模型中表现出良好的体内活性。
• [EN] 2,5-DIARYL SELENOPHENE COMPOUNDS, AZA 2,5-DIARYL THIOPHENE COMPOUNDS, AND THEIR PRODRUGS AS ANTIPROTOZOAL AGENTS<br/>[FR] COMPOSÉS DE 2,5-DIARYLSÉLÉNOPHÈNE, COMPOSÉS D'AZA-2,5-DIARYLTHIOPHÈNE ET LEURS PROMÉDICAMENTS UTILISÉS EN TANT QU'AGENTS ANTIPROTOZOAIRES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2009051796A2

  公开（公告）日：2009-04-23

  Novel dicationic 2,5-diaryl selenophene compounds are described. Also described are novel aza analogues of dicationic 2,5-diaryl thiophenes. The presently disclosed dicationic compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, and/or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic compounds display good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.