4-hydrazinyl-1-methyl-1H-pyrazole dihydrochloride | 1803599-63-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-hydrazinyl-1-methyl-1H-pyrazole dihydrochloride
• 英文别名: (1-methylpyrazol-4-yl)hydrazine;dihydrochloride
• CAS: 1803599-63-4
• 化学式: C4H10Cl2N4
• mdl: MFCD27980880
• 分子量: 185.05
• InChiKey: MSTXOFQLKDHSRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.21
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.9
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• 2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER
  申请人：Bayer Aktiengesellschaft

  公开号：EP3580211B1

  公开（公告）日：2020-12-02
• SULPHUR SUBSTITUTED 3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
  申请人：Bayer Aktiengesellschaft

  公开号：US20200299269A1

  公开（公告）日：2020-09-24

  The present invention covers sulphur substituted 3-oxo-2,3-dihydropyridazine-4 carboxamide compounds of general formula (I): (I) in which R 1 , R 2 , A, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.