N-(5-methyl-pyrazin-2-ylmethyl)-3-(5-methyl-pyridin-2-yl)-5-(8-oxo-7,8-dihydro-purin-9-yl)-benzamide | 1258950-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(5-methyl-pyrazin-2-ylmethyl)-3-(5-methyl-pyridin-2-yl)-5-(8-oxo-7,8-dihydro-purin-9-yl)-benzamide
• 英文别名: N-[(5-methylpyrazin-2-yl)methyl]-3-(5-methylpyridin-2-yl)-5-(8-oxo-7H-purin-9-yl)benzamide
• CAS: 1258950-35-4
• 化学式: C₂₄H₂₀N₈O₂
• 分子量: 452.475
• InChiKey: LBHYSUNETNFKQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
  申请人：Chen Li

  公开号：US20100324069A1

  公开（公告）日：2010-12-23

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X 3 and/or a P2X 2/3 receptor antagonists and methods of making the compounds.

  化合物的化学式I：或其药用可接受的盐，其中，X、Y、R1、R2、R3、R4、R5、R6和R7的定义如本文所述。还公开了使用这些化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法，以及制备这些化合物的方法。
• OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X 2/3 ANTAGONISTS
  申请人：CHEN Li

  公开号：US20120083500A1

  公开（公告）日：2012-04-05

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X 3 and/or a P2X 2/3 receptor antagonists and methods of making the compounds.

  化合物I的公式或其药学上可接受的盐，其中，X、Y、R1、R2、R3、R4、R5、R6和R7如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法以及制备该化合物的方法。
• NOVEL OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2445889A1

  公开（公告）日：2012-05-02
• SUBSTITUTED PYRIDINES AS P2X3 AND P2X2/3 ANTAGONISTS
  申请人：Roche Palo Alto LLC

  公开号：US20170056398A1

  公开（公告）日：2017-03-02

  Methods of treating diseases associated with P2X 3 and/or a P2X 2/ with compounds formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein.
• US8093275B2
  申请人：——

  公开号：US8093275B2

  公开（公告）日：2012-01-10