(S)-1-[5-(2,6-Dimethyl-pyridin-4-yl)-3-(3-fluoro-5-methoxy-phenylamino)-[1,2,4]triazol-1-yl]-butan-2-ol HCl salt | 1145355-55-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-1-[5-(2,6-Dimethyl-pyridin-4-yl)-3-(3-fluoro-5-methoxy-phenylamino)-[1,2,4]triazol-1-yl]-butan-2-ol HCl salt
• 英文别名: (S)-1-[5-(2,6-dimethylpyridin-4-yl)-3-(3-fluoro-5-methoxyanilino)-[1,2,4]triazol-1-yl]butan-2-ol hydrochloride；(S)-1-[5-(2,6-dimethyl-pyridin-4-yl)-3-(3-fluoro-5-methoxy-anilino)-[1,2,4]triazol-1-yl]-butan-2-ol HCl salt；(S)-1-[5-(2,6-Dimethylpyridin-4-yl)-3-(3-fluoro-5-methoxyphenylamino)-[1,2,4]triazol-1-yl]butan-2-ol, HCl；(2S)-1-[5-(2,6-dimethylpyridin-4-yl)-3-(3-fluoro-5-methoxyanilino)-1,2,4-triazol-1-yl]butan-2-ol;hydrochloride
• CAS: 1145355-55-0
• 化学式: C₂₀H₂₄FN₅O₂*ClH
• 分子量: 421.902
• InChiKey: FPPNHYCPLYNMHV-LMOVPXPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.04
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  85.1
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] TRISUBSTITUTED 1,2,4-TRIAZOLES<br/>[FR] 1,2,4-TRIAZOLES TRISUBSTITUÉS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009050186A1

  公开（公告）日：2009-04-23

  The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors which have the capability of increasing the efficacyofnicotinic receptor agonists.

  本发明涉及替代的1-(烷基)-3-苯胺-5-芳基三唑衍生物及其类似物或药学上可接受的盐，制备它们的方法，含有它们的药物组合物以及它们在治疗中的应用，根据公式(I)。该发明特别涉及对尼古丁乙酰胆碱受体的强效正向变构调节剂，具有增加尼古丁受体激动剂效力的能力。
• TRISUBSTITUTED 1,2,4 TRIAZOLES
  申请人：Thuring Johannes Wilhelmus John F.

  公开号：US20100216846A1

  公开（公告）日：2010-08-26

  The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors which have the capability of increasing the efficacy of nicotinic receptor agonists.

  本发明涉及取代的1-(烷基)-3-苯胺-5-芳基三唑衍生物和类似物或其药学上可接受的盐，其制备过程，包含它们的制药组合物以及它们在治疗中的应用，根据公式(I)。本发明特别涉及能够增加烟碱乙酰胆碱受体激动剂功效的强效正变构调节剂。
• TRISUBSTITUTED 1,2,4-TRIAZOLES
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP2212309B1

  公开（公告）日：2013-06-19
• US8440701B2
  申请人：——

  公开号：US8440701B2

  公开（公告）日：2013-05-14