N-Phenyl-4-(5-Phenyl-1h-Pyrazol-4-Yl)pyrimidin-2-Amine | 541507-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-Phenyl-4-(5-Phenyl-1h-Pyrazol-4-Yl)pyrimidin-2-Amine
• CAS: 541507-74-8
• 化学式: C₁₉H₁₅N₅
• 分子量: 313.4
• InChiKey: GHIDSWLDHRXNQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PHENYL-[4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-Yl)-AMINE DERIVATIVES<br/>[FR] DERIVES DE PHENYL-[4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-YL)-AMINE
  申请人：NOVARTIS AG

  公开号：WO2004005282A1

  公开（公告）日：2004-01-15

  The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl)-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives - alone or in combination with one or more other pharmaceutically active compounds - for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

  这项发明涉及苯基-[4-(3-苯基-1H-吡唑-4-基)-嘧啶-2-基)-胺衍生物，以及其制备方法，包括含有这种衍生物的药物组合物，以及使用这种衍生物 - 单独或与一个或多个其他药用活性化合物结合 - 制备用于治疗增生性疾病，如肿瘤的药物组合物。
• [EN] PHENYL-[4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IGF-IR INHIBITORS<br/>[FR] DERIVES DE PHENYL-[4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-YL]-AMINE UTILISES COMME INHIBITEURS DU RECEPTEUR IGF-1R
  申请人：NOVARTIS AG

  公开号：WO2005068452A1

  公开（公告）日：2005-07-28

  The present invention relates to a compound of formula (I) and derivatives thereof. Furthermore, the invention relates to the use of such compounds as medicaments. In addition, the invention relates to the use of such compounds for manufacturing a medicament useful for treating proliferative diseases.

  本发明涉及一种具有化学式(I)及其衍生物的化合物。此外，该发明涉及将这种化合物用作药物的用途。此外，该发明涉及将这种化合物用于制造用于治疗增殖性疾病的药物的用途。
• Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yI)-amine derivatives
  申请人：Furet Pascal

  公开号：US20060106027A1

  公开（公告）日：2006-05-18

  The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

  本发明涉及苯基-[4-(3-苯基-1H-吡唑-4-基)-嘧啶-2-基]-胺衍生物及其制备方法，涉及含有这种衍生物的制药组合物以及使用这种衍生物 - 单独或与一种或多种其他药理活性化合物结合 - 制备用于治疗增生性疾病，如肿瘤的制药组合物。
• Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives as igf-ir inhibitors
  申请人：Garcia-Echeverria Carlos

  公开号：US20090149469A1

  公开（公告）日：2009-06-11

  The present invention relates to a compound of formula I and derivatives thereof. Furthermore, the invention relates to the use of such compounds as medicaments. In addition, the invention relates to the use of such compounds for manufacturing a medicament useful for treating proliferative diseases.

  本发明涉及公式I的化合物及其衍生物。此外，本发明涉及将这些化合物用作药物的用途。此外，本发明还涉及将这些化合物用于制造用于治疗增殖性疾病的药物的用途。
• PHENYL-(4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-Yl)-AMINE DERIVATIVES
  申请人：Novartis AG

  公开号：EP1521749A1

  公开（公告）日：2005-04-13