(2R)-3-(4-{[3-(2,6-dichlorophenyl)isoxazol-5-yl]methyl}piperazinyl)-1-[2-(4-fluorophenyl)benzoxazol-5-yloxy]propan-2-ol | 1055972-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2R)-3-(4-{[3-(2,6-dichlorophenyl)isoxazol-5-yl]methyl}piperazinyl)-1-[2-(4-fluorophenyl)benzoxazol-5-yloxy]propan-2-ol
• 英文别名: (2R)-1-[4-[[3-(2,6-dichlorophenyl)-1,2-oxazol-5-yl]methyl]piperazin-1-yl]-3-[[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]oxy]propan-2-ol
• CAS: 1055972-25-2
• 化学式: C₃₀H₂₇Cl₂FN₄O₄
• 分子量: 597.473
• InChiKey: KCRLQNPECVSULP-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  88
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Substituted heterocyclic compounds
  申请人：——

  公开号：US20040176383A1

  公开（公告）日：2004-09-09

  Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.

  本发明涉及新型杂环衍生物，可用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常，间歇性跛行，普林兹梅塔尔（变异）心绞痛，稳定和不稳定心绞痛，运动诱发性心绞痛，充血性心力衰竭和心肌梗死。这些化合物还可用于治疗糖尿病，并提高哺乳动物的高密度脂蛋白血浆水平。
• SUBSTITUTED HETEROCYCLIC COMPOUNDS
  申请人：CV Therapeutics Inc.

  公开号：EP1583760A2

  公开（公告）日：2005-10-12
• US7056924B2
  申请人：——

  公开号：US7056924B2

  公开（公告）日：2006-06-06
• [EN] SUBSTITUTED HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSES HETEROCYCLIQUE SUBSTITUES
  申请人：CV THERAPEUTICS INC

  公开号：WO2004067506A2

  公开（公告）日：2004-08-12

  Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.