2-amino-5-methyl-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]triazine-4-sulfonic acid | 53785-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-amino-5-methyl-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]triazine-4-sulfonic acid
• 英文别名: 2-Amino-3,4-dihydro-5-methyl-7-propylimidazo[5,1-f]-as-triazine-4-sulphonic acid；2-amino-5-methyl-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazine-4-sulfonic acid
• CAS: 53785-84-5
• 化学式: C₉H₁₅N₅O₃S
• 分子量: 273.316
• InChiKey: ZQFROBYSHHKIFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-2-ylamine 以100%的产率得到
  参考文献：
  名称：

  CLARKE R. W.; GARSIDE S. C.; LUNTS L. H. C.; HARTLEY D.; HORNBY R.; OXFOR+, J. CHEM. SOC. PERKIN TRANS., PART 1, 1979, NO 4, 1120-1124

  摘要：

  DOI：

文献信息

• Imidazo [5,1-f]-as-triazines
  申请人：Allen & Hanburys Limited

  公开号：US03941785A1

  公开（公告）日：1976-03-02

  Compounds of the general formula: ##SPC1## In which: R.sub.1 and R.sub.2 which may be the same or different, represent a hydrogen atom or an alkyl group which may optionally be substituted by an aryl group, or represents an alkanoyl, aroyl or alkanesulphonyl group; R.sub.3 represents a hydrogen atom, or an alkyl group which may optionally be substituted by an aryl group, or represents an alkenyl, aryl or alkylthio group; R.sub.4 represents a hydrogen atom or an alkyl group; and R.sub.5 represents a hydrogen atom or an aryl or alkyl group, which alkyl group may optionally be substituted by a cycloalkyl group; And physiologically acceptable salts and derivatives thereof and addition products formed by nucleophilic addition. These compounds act as spasmolytics and phosphodiasterase inhibitors and have cardiotonic and diuretic properties. They are also of use in the treatment of skin disorders and gout.

  通式为##SPC1##的化合物：其中，R.sub.1和R.sub.2可能相同也可能不同，代表氢原子或烷基，该烷基可以被芳基取代，或代表烷酰基，芳酰基或烷基磺酰基；R.sub.3代表氢原子，或烷基，该烷基可以被芳基取代，或代表烯基，芳基或烷硫基；R.sub.4代表氢原子或烷基；R.sub.5代表氢原子或芳基或烷基，该烷基可以被环烷基取代；以及生理上可接受的盐和衍生物，以及由亲核加成形成的加成物。这些化合物作为平滑肌松弛剂和磷酸二酯酶抑制剂，并具有心脏强心和利尿作用。它们也用于治疗皮肤疾病和痛风。