9-(3-(4-methylpiperazin-1-yl)propyl)-9H-carbazole | 102240-45-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-(3-(4-methylpiperazin-1-yl)propyl)-9H-carbazole
• 英文别名: 9-[3-(4-Methylpiperazin-1-yl)propyl]carbazole
• CAS: 102240-45-9
• 化学式: C₂₀H₂₅N₃
• 分子量: 307.439
• InChiKey: LSCHXFIPSBDLLQ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  9-(3-(4-methylpiperazin-1-yl)propyl)-9H-carbazole 在 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 (E)-1,3,3-trimethyl-2-(2-(9-(3-(4-methylpiperazin-1-yl)propyl)-9H-carbazol-3-yl)vinyl)-3H-indol-1-ium iodide
  参考文献：
  名称：

  Discovery of a far-red carbazole-benzoindolium fluorescent ligand that selectively targets mitochondrial DNA and suppresses breast cancer growth

  摘要：

  DOI：

  10.1016/j.ejmech.2023.116046
• 作为产物：
  描述：

  咔唑 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 2.0h， 生成 9-(3-(4-methylpiperazin-1-yl)propyl)-9H-carbazole
  参考文献：
  名称：

  Discovery of a far-red carbazole-benzoindolium fluorescent ligand that selectively targets mitochondrial DNA and suppresses breast cancer growth

  摘要：

  DOI：

  10.1016/j.ejmech.2023.116046

文献信息

• SMALL MOLECULE COMPOUNDS FOR STEM CELL DIFFERENTIATION
  申请人：Mercola Mark

  公开号：US20100159596A1

  公开（公告）日：2010-06-24

  Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof: R 1 is independently hydrogen or (C 1 -C 6 )alkyl; R 2 is independently hydrogen, (C 1 -C 6 )alkyl, aryl, or heteroaryl; R 2′ is independently hydrogen, (C 1 -C 6 )alkyl, CF 3 or C 2 F 5 ; R 3 is independently (C 1 -C 6 )alkyl, aryl, 2-tetrahydrofurylmethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R 2 and R 3 may be joined together to form a 5 or 6 member ring lactone; R 4 is independently hydrogen, (C 1 -C 6 )alkyl, a 2- or 4-R 5 -substituted aromatic ring selected from a 4-R 5 -phenyl or a 2-R 5 -5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R 5 , R 5′ , R 6 , R 6′ , R 7 , R 7′ , are each independently hydrogen, (C 1 -C 6 )alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.

  提供干细胞分化的方法和小分子化合物。可以使用的一类化合物的一个示例由结构IA或IB表示，以自由碱基或其药学上可接受的盐，水合物，溶剂或N-氧化物的形式存在：R1独立地是氢或（C1-C6）烷基; R2独立地是氢，（C1-C6）烷基，芳基或杂环芳基; R2'独立地是氢，（C1-C6）烷基，CF3或C2F5; R3独立地是（C1-C6）烷基，芳基，2-四氢呋喃甲基，脂肪族三级胺或4-甲氧基苄基; 或者R2和R3可以结合形成5或6元环内酯; R4独立地是氢，（C1-C6）烷基，2-或4-R5-取代的芳环，选自4-R5-苯基或2-R5-5-吡啶基，芳基，杂环芳基，脂肪族三级胺或卤素; R5，R5'，R6，R6'，R7，R7'独立地是氢，（C1-C6）烷基，芳基，可选取代的苯基，杂环芳基，杂环环，脂肪族三级胺或卤素。
• 9-(3-(3,5-cis-Dimethylpiperazino)propyl)-carbazole, its preparation and pharmaceutical compositions containing it
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0012208A2

  公开（公告）日：1980-06-25

  This invention is directed to the compound 9-[3-(3,5- cis-dimethylpiperazino)propyl)carbazole, salts thereof and solvates of the salts which are useful in treating aggression and/or psychoses in man and also in treating aggression in animals such as dogs, swine, horses and cattle. The invention is also directed to methods for the preparation of the carbazole, salts and solvates, to pharmaceutical compositions containing them, the preparation of such compositions and the use of the carbazole, salts and solvates in human and veterinary medicine. Also provided by the invention are intermediates of value in the preparation of the carbazole, salts and solvates by the methods described.

  本发明涉及化合物9-[3-(3,5-顺式二甲基哌嗪)丙基)咔唑、其盐类和盐类的溶解物，它们可用于治疗人的攻击行为和/或精神病，也可用于治疗动物如狗、猪、马和牛的攻击行为。本发明还涉及咔唑、其盐类和溶物的制备方法、含有它们的药物组合物、此类组合物的制备以及咔唑、其盐类和溶物在人类和兽医中的使用。本发明还提供了通过所述方法制备咔唑、盐和溶液的中间体。
• US4379160A
  申请人：——

  公开号：US4379160A

  公开（公告）日：1983-04-05
• US9012217B2
  申请人：——

  公开号：US9012217B2

  公开（公告）日：2015-04-21
• [EN] HEPATITIS C VIRUS ENTRY INHIBITORS<br/>[FR] INHIBITEURS DE LA PÉNÉTRATION DU VIRUS DE L'HÉPATITE C
  申请人：IMMUSOL INC

  公开号：WO2008021745A2

  公开（公告）日：2008-02-21

  [EN] The present invention relates to the use of tricyclic diphenylamine derivative compounds for prevention and/or treatment of Hepatitis C virus (HCV) infection by inhibiting HCV entry into permissive cells.
  [FR] La présente invention concerne l'utilisation de composés dérivés de la diphénylamine tricyclique pour la prévention et/ou le traitement d'une infection par le virus de l'hépatite C (Hepatitis C Virus : HCV) en inhibant la pénétration du HCV dans les cellules permissives.