Ethyl [2-(4-chlorophenyl)-5-phenyl-1,3-thiazol-4-yl]acetate | 105584-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Ethyl [2-(4-chlorophenyl)-5-phenyl-1,3-thiazol-4-yl]acetate
• 英文别名: ethyl 2-[2-(4-chlorophenyl)-5-phenyl-1,3-thiazol-4-yl]acetate
• CAS: 105584-38-1
• 化学式: C₁₉H₁₆ClNO₂S
• 分子量: 357.9
• InChiKey: YBNZZODQEOWZJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl [2-(4-chlorophenyl)-5-phenyl-1,3-thiazol-4-yl]acetate 、 氨 在 甲醇 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以to obtain 2-(4-chloro-phenyl)-5-phenylthiazol-4-yl acetamide (4.2 g)的产率得到2-(4-Chlorophenyl)-5-phenylthiazol-4-yl acetamide
  参考文献：
  名称：

  Large conductance calcium-activated K channel opener

  摘要：

  一种大导电性钙激活的K通道开放剂，其作为活性成分包含以下式子（I）所代表的含氮5元杂环化合物，其中X代表N—R4、O或S，R1和R2各自独立地代表氢、卤素、羧基、氨基、较低的烷基、较低的烷氧基羰基、较低的烯基、环-较低的烷基、氨基甲酰基、芳香族、杂环或杂环取代的羰基基团，R3代表芳香族、杂环或较低的烷基基团，而R4代表氢或较低的烷基基团，或其药学上可接受的盐。

  公开号：

  US07759373B2

文献信息

• Large conductance calcium-activated k channel opener
  申请人：——

  公开号：US20040127527A1

  公开（公告）日：2004-07-01

  A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): 1 wherein X represents N—R 4 , O or S, R 1 and R 2 each independently represent hydrogen, halogen, carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R 3 represents aryl, heterocyclic or lower alkyl group, and R 4 represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof.

  一种大导电性钙激活的K通道开放剂，包括以下式子（I）所表示的含氮5元杂环化合物作为活性成分：1其中，X代表N-R4，O或S，R1和R2各自独立地代表氢、卤素、羧基、氨基、低级烷基、低级烷氧羰基、低级烯基、环状低级烷基、氨基甲酰基、芳香族、杂环或杂环取代的羰基基团，R3代表芳香族、杂环或低级烷基基团，R4代表氢或低级烷基基团，或其药学上可接受的盐。
• Large conductance calcium-activated K channel opener
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：US07759373B2

  公开（公告）日：2010-07-20

  A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X represents N—R4, O or S, R1 and R2 each independently represent hydrogen, halogen, carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R3 represents aryl, heterocyclic or lower alkyl group, and R4 represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof.

  一种大导电性钙激活的K通道开放剂，其作为活性成分包含以下式子（I）所代表的含氮5元杂环化合物，其中X代表N—R4、O或S，R1和R2各自独立地代表氢、卤素、羧基、氨基、较低的烷基、较低的烷氧基羰基、较低的烯基、环-较低的烷基、氨基甲酰基、芳香族、杂环或杂环取代的羰基基团，R3代表芳香族、杂环或较低的烷基基团，而R4代表氢或较低的烷基基团，或其药学上可接受的盐。
• IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP1432690A2

  公开（公告）日：2004-06-30
• US7759373B2
  申请人：——

  公开号：US7759373B2

  公开（公告）日：2010-07-20
• [EN] LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER<br/>[FR] SUBSTANCE D'OUVERTURE DU CANAL K ACTIVEE PAR LE CALCIUM A GRANDE CONDUCTANCE
  申请人：TANABE SEIYAKU CO

  公开号：WO2002083111A2

  公开（公告）日：2002-10-24

  A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X represents N-R4, O or S, R1 and R 2 each independently represent hydrogen, halogen carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R3 represents aryl, heterocyclic or lower alkyl group, and R4 represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof and its use for the preparation of a medicament for the phophylaxis and/or treatment of pollakiuria or urinary incontinence.