[5-(3-bromo-phenyl)-4-methyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | 1107659-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [5-(3-bromo-phenyl)-4-methyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone
• 英文别名: [3-(3-bromophenyl)-4-methyl-1H-pyrazol-5-yl]-[3-(diethylamino)pyrrolidin-1-yl]methanone
• CAS: 1107659-05-1
• 化学式: C₁₉H₂₅BrN₄O
• 分子量: 405.338
• InChiKey: REWRGCDGEDBTCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [5-(3-bromo-phenyl)-4-methyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone 、 三甲基乙炔基硅 在 copper(l) iodide 、 四(三苯基膦)钯 哌啶 作用下， 反应 3.67h， 以64%的产率得到(3-diethylamino-pyrrolidin-1-yl)-[4-methyl-5-(3-trimethylsilanylethynyl-phenyl)-1H-pyrazol-3-yl]-methanone
  参考文献：
  名称：

  PYRAZOL DERIVATIVES

  摘要：

  这项发明涉及式(I)的新型吡唑衍生物， 其中 R 1 ，R 2 ，R 3 ，R 4 ，X和Y如本文所定义，以及其生理上可接受的盐。这些化合物是CCR-2受体和/或CCR-5受体的拮抗剂，可用作药物。

  公开号：

  US20090029963A1
• 作为产物：
  描述：

  5-(3-bromo-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid 、 3-(二乙氨基)吡咯烷 以gave the title compound in 91% yield as off-white foam的产率得到[5-(3-bromo-phenyl)-4-methyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone
  参考文献：
  名称：

  Pyrazol derivatives

  摘要：

  本发明涉及公式（I）的新型吡唑衍生物，其中R1、R2、R3、R4、X和Y的定义如本文所述，以及其生理上可接受的盐。这些化合物是CCR-2受体和/或CCR-5受体的拮抗剂，可用作药物。

  公开号：

  US07977358B2

文献信息

• NEW PYRAZOL DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2182953A2

  公开（公告）日：2010-05-12
• HYDRAULIC OIL FOR USE IN CONSTRUCTION MACHINERY
  申请人：SHELL INTERNATIONAL RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP2193186A1

  公开（公告）日：2010-06-09
• US7977358B2
  申请人：——

  公开号：US7977358B2

  公开（公告）日：2011-07-12
• [EN] NEW PYRAZOL DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS PYRAZOLÉS
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009013211A2

  公开（公告）日：2009-01-29

  The invention is concerned with novel pyrazol derivatives of formula (I), wherein formula (II), R1, R2, R3, R4, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor and/or CCR-5 receptor and can be used as medicaments.
• [EN] HYDRAULIC OIL FOR USE IN CONSTRUCTION MACHINERY<br/>[FR] HUILE HYDRAULIQUE POUR UNE UTILISATION DANS DES ENGINS DE CONSTRUCTION
  申请人：SHOWA SHELL SEKIYU

  公开号：WO2009040658A1

  公开（公告）日：2009-04-02

  Hydraulic oil for use in construction machinery, wherein the hydraulic oil comprises a poly(meth)acrylate of weight average molecular weight in the range of from 30,000 to 100,000 in a highly refined base oil but does not incorporate an oiliness agent, and wherein the kinetic viscosity at 60°C is in the range of from 25 to 60 mm²/s, the kinetic viscosity at 80°C is in the range of from 15 to 34 mm²/s, the viscosity index is in the range of from 200 to 220, and the low temperature cranking viscosity at 25°C is in the range of from 1000 to 8000 mPa.s. The hydraulic oil of the present invention not only has a high kinetic viscosity in the high-temperature domain even though the incorporation of an oiliness agent is omitted, and can thereby effect satisfactory operation efficiently and which has excellent braking characteristics, but which also has a low viscosity in the low-temperature domain and so has excellent low-temperature performance.