2-[3-(4-Methylquinolin-1-ium-1-yl)propyl]isoindole-1,3-dione;bromide | 1018858-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[3-(4-Methylquinolin-1-ium-1-yl)propyl]isoindole-1,3-dione;bromide
• CAS: 1018858-27-9
• 化学式: Br*C₂₁H₁₉N₂O₂
• 分子量: 411.298
• InChiKey: JWKNBRXUKOSYTO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.13
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[3-(4-Methylquinolin-1-ium-1-yl)propyl]isoindole-1,3-dione;bromide 在 盐酸 、 copper(l) iodide 、 copper(ll) sulfate pentahydrate 、 sodium ascorbate 、 三乙胺 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  双发色染料，用于染料-蛋白质氟模块的波长转换†

  摘要：

  染料蛋白质的荧光模块由荧光染料和单链抗体片段组成，它们形成明亮的荧光非共价复合物。该报告描述了两种新的双色性染料，它们扩展了现有荧光模块的激发或发射波长范围。在一种情况下，将荧光噻唑橙（TO）连接到能量受体染料Cy5上。结合识别TO的蛋白质后，由于从TO到Cy5的有效能量转移，红色发射取代了结合到同一蛋白质的单色TO所观察到的绿色发射。单独地，TO连接到作为能量供体的香豆素上。香豆素-TO和与蛋白质结合的TO观察到相同的绿色发射，但是有效的能量转移允许香豆素-TO的紫色激发，而更长的波长，单色TO的蓝色激发。两种双色团各自的蛋白质均显示出较低的纳摩尔K D值，> 95％的能量转移效率和较高的荧光量子产率。

  DOI：

  10.1039/c4ob02522a
• 作为产物：
  描述：

  4-甲基喹啉 、 N-(3-溴丙基)苯二胺 以 乙醇 为溶剂， 以53%的产率得到2-[3-(4-Methylquinolin-1-ium-1-yl)propyl]isoindole-1,3-dione;bromide
  参考文献：
  名称：

  双发色染料，用于染料-蛋白质氟模块的波长转换†

  摘要：

  染料蛋白质的荧光模块由荧光染料和单链抗体片段组成，它们形成明亮的荧光非共价复合物。该报告描述了两种新的双色性染料，它们扩展了现有荧光模块的激发或发射波长范围。在一种情况下，将荧光噻唑橙（TO）连接到能量受体染料Cy5上。结合识别TO的蛋白质后，由于从TO到Cy5的有效能量转移，红色发射取代了结合到同一蛋白质的单色TO所观察到的绿色发射。单独地，TO连接到作为能量供体的香豆素上。香豆素-TO和与蛋白质结合的TO观察到相同的绿色发射，但是有效的能量转移允许香豆素-TO的紫色激发，而更长的波长，单色TO的蓝色激发。两种双色团各自的蛋白质均显示出较低的纳摩尔K D值，> 95％的能量转移效率和较高的荧光量子产率。

  DOI：

  10.1039/c4ob02522a

文献信息

• Optical biosensors
  申请人：CARNEGIE MELLON UNIVERSITY

  公开号：EP2629094A1

  公开（公告）日：2013-08-21

  Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell. The biosensors may provide a signal when the biosensor is targeted and/or in response to a property of the cell or organism such as membrane potential, ion concentration or enzyme activity.

  本文提供了生物传感器、包含生物传感器的组合物以及在活细胞和生物体中使用生物传感器的方法。这些生物传感器可选择性地靶向细胞内的某些区域或结构。当生物传感器被锁定和/或响应细胞或生物体的特性（如膜电位、离子浓度或酶活性）时，生物传感器可提供信号。
• Synthesis and study of nucleic acids interactions of novel monomethine cyanine dyes
  作者：Stefka Kaloyanova、Ivo Crnolatac、Nedyalko Lesev、Ivo Piantanida、Todor Deligeorgiev

  DOI：10.1016/j.dyepig.2011.08.019

  日期：2012.3

  Six asymmetric monomethine cyanine dyes have been synthesized and their spectral characteristics and interaction with double stranded (ds)DNA have been investigated for their prospective use as fluorescent markers in molecular biology. Therefore, the non-covalent binding of the compounds with dsDNA was explored. Apart from the fluorescence spectroscopy, the study includes UV/Vis spectrophotometry and circular dichroism spectroscopy, as well as the thermal melting experiments. Although the compounds show relatively low binding affinity toward dsDNA and do not have intrinsic fluorescence, in the presence of dsDNA they exhibited considerable enhancement in fluorescence intensity. Therefore the studied dyes show interesting platform for future modifications directed toward more sequence selective derivatives. The compound with the highest affinity toward dsDNA showed interesting anti-proliferative potential and specificity. (C) 2011 Elsevier Ltd. All rights reserved.
• Synthesis and fluorescence characteristics of novel asymmetric cyanine dyes for DNA detection
  作者：Stefka Kaloyanova、Valeriya M. Trusova、Galyna P. Gorbenko、Todor Deligeorgiev

  DOI：10.1016/j.jphotochem.2010.10.002

  日期：2011.1

  Sixteen new asymmetric monomethine cyanine dyes have been synthesized and their spectral characteristics and interaction with double stranded DNA have been investigated. The dyes absorb in the region 453-519 nm and have molar absorptivities in the range 37.900-93.100IM(-1) cm(-1). The dyes do not have intrinsic fluorescence, but in the presence of dsDNA they exhibited a significant enhancement in fluorescence. The most pronounced increase was found for D9, D10, D12 and D16 allowing the recommendation of these dyes as the most sensitive DNA markers. Thermodynamic analysis of cyanine-DNA complexation was carried out using the McGhee & von Hippel non-cooperative excluded site model, and binding parameters have been derived. A hypothesis describing the DNA-dye binding mode has been proposed. (C) 2010 Elsevier B.V. All rights reserved.
• OPTICAL BIOSENSORS
  申请人：Carnegie Mellon University

  公开号：EP2111553A2

  公开（公告）日：2009-10-28
• US8664364B2
  申请人：——

  公开号：US8664364B2

  公开（公告）日：2014-03-04