N-[(2,4-dinitro-5-benzotriazolylphenyl)]-4-aminobutyl triphosphate | 1191406-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[(2,4-dinitro-5-benzotriazolylphenyl)]-4-aminobutyl triphosphate
• CAS: 1191406-76-4
• 化学式: C₁₆H₁₉N₆O₁₄P₃
• 分子量: 612.28
• InChiKey: PBOQUUDDSXONGU-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 三丁基焦磷酸铵 作用下， 反应 1.0h， 生成 N-[(2,4-dinitro-5-benzotriazolylphenyl)]-4-aminobutyl triphosphate
  参考文献：
  名称：

  Structure-functional analysis of interactions of terminal deoxynucleotidyl transferase with new non-nucleoside substrates

  摘要：

  New non-nucleoside esters of phosphoric acid containing various hydrophobic groups, namely (1) N-(2-tripticencarbonyl)-4-aminobutyl; (2) 5-phenylsubstituted N-(2,4-dinitrophenyl)-4-aminobutyl; (3) N-(4-phenylbenzoyl)- and N-(4-(N-benzylamino)benzoyl)-2-aminoethyl groups, as well as (4) diphenylmethyl and fluorenyl groups were synthesized and studied as substrates of terminal deoxynucleotidyl transferase. With the exception of the two latter derivatives, all the analogues displayed substrate properties and could incorporate into the deoxyoligonucleotide 3'-end. As it was shown in biochemical experiments and by computer modeling, a linker joining the triphosphate and hydrophobic fragments of the molecule was necessary for these compounds to display substrate properties.

  DOI：

  10.1134/s1068162009030091