tBuP(CH2CO2Me)2 | 171775-93-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tBuP(CH2CO2Me)2
• 英文别名: Methyl 2-[tert-butyl-(2-methoxy-2-oxoethyl)phosphanyl]acetate
• CAS: 171775-93-2
• 化学式: C₁₀H₁₉O₄P
• 分子量: 234.232
• InChiKey: BGTFYIUSHCDBNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (mesitylene)osmium dichloride 、 tBuP(CH2CO2Me)2 以 二氯甲烷 为溶剂， 以85%的产率得到
  参考文献：
  名称：

  Mesitylene Osmium(II) Complexes Containing the Functional Phosphane tBuP(CH₂CO₂Me)₂ and Anionic Species Derived Thereof as Bi- and Tridentate Ligands

  摘要：

  摘要：二氯合铼(II)化合物[(mes)OsCl₂(L)] (2) 其中 L = tBuP(CH₂CO₂Me)₂ 与一或两当量的AgPF₆ 反应，形成含有膦二酯基配体的单价或双价络合物3和4。在水存在下，络合物4发生部分水解，生成定量产率的二氟磷酸铼(II)衍生物5。用两当量的KOtBu处理4，通过去质子化L的两个CH₂基团，形成中性络合物6，其中二阴离子配体|tBuP(CHCO₂Me)₂]^2- 的一个PCHCO₂Me单元形成五元环，另一个PCHCO₂Me单元与金属形成三元环。6与水的反应选择性地导致形成含有膦二酯基(羧酸盐) [tBuP(CH₂CO₂)₂]^2- 作为三脚架配体的螯合物7 的生成。

  DOI：

  10.1515/znb-1998-5-608
• 作为产物：
  描述：

  叔-丁基-二(三甲基硅烷基)膦 、 氯乙酸甲酯 以 苯 为溶剂， 反应 3.0h， 以69%的产率得到tBuP(CH2CO2Me)2
  参考文献：
  名称：

  Wolfsberger, Werner; Bank, Juergen; Werner, Helmut, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1995, vol. 50, # 9, p. 1319 - 1328

  摘要：

  DOI：

文献信息

• Areneruthenium(II) Complexes with Functionalized Phosphines Coordinating as Mono-, Bi- or Tridentate Ligands
  作者：Helmut Werner、Jürgen Bank、Bettina Windmüller、Olaf Gevert、Werner Wolfsberger

  DOI：10.1002/1522-2675(20011017)84:10<3162::aid-hlca3162>3.0.co;2-r

  日期：2001.10.17

  -O-O2PF2)]PF6, 15 – 17, of which 17 (arene=mes; R=tBu) has been characterized by X-ray crystallography. Compounds 13 and 14 react with 2 equiv. of KOtBu in tBuOH/toluene to give the unsymmetrical complexes [Ru(mes)κ3-P,C,O-RP(CHCO2Me)(CH=C(O)OMe)}], 18 and 19, containing both a five-membered phosphinoenolate and a three-membered phosphinomethanide ring. The molecular structure of compound 18 has been

  钌 (II) 化合物 [Ru(p-cym)Cl2κ-P-iPrP(CH2CH2OMe)2}]、3 和 [Ru(arene)Cl2κ-P-RP(CH2CO2Me)2}] 4 – 7 (芳烃=p-cym (=1-甲基-4-异丙基苯), mes (=1,3,5-三甲基苯); R=iPr, tBu) 由二聚体 [Ru(arene)Cl2]2 和相应的官能化膦。用 1 equiv 处理 6 和 7。AgPF6 提供单阳离子配合物 [Ru(mes)Clκ2-P,O-RP(CH2C(O)OMe)(CH2CO2Me)}]PF6、10 和 11，而 5 – 7 与 2 equiv 的相关反应。AgPF6 产生双阳离子化合物 [Ru(p-cym)κ3-P,O,O-tBuP(CH2C(O)OMe)2}](PF6)2 (12) 和 [Ru(mes)κ3-P ,O,O-RP(CH2C(O)OMe)2}](PF6)2
• Ruthenium(<scp>II</scp>) complexes with a new potentially trifunctional phosphinoester and its enolate as ligands
  作者：Jürgen Bank、Paul Steinert、Bettina Windmüller、Werner Wolfsberger、Helmut Werner

  DOI：10.1039/dt9960001153

  日期：——

  Both RuCl3 . nH(2)O and [RuCl2(PPh(3))(3)] reacted with PBu(t)(CH(2)CO(2)Me)(2) to give a mixture of two isomeric ruthenium(II) complexes [RuCl2PBu(t)[CH2C(OMe)=O](CH(2)CO(2)Me)-kappa(3)P,O}(2)] 1a and 1b (ratio 3:1) which contain two molecules of the ester as bidentate chelating ligands. Treatment of la,lb with AgPF6 led, after abstraction of one chloride ligand, to the cationic complex [RuClPBu(t)[CH2C(OMe)=O](2)-kappa(3)P,O,O}PBu(t)[CH2C(OMe)=O] [CH(2)CO(2)Me)-kappa(2)P,O}PF6 2 in which one molecule of the phosphinoester is a bi- and the other a tri-dentate ligand. Reaction of 2 with KOBu(1) or NaN(SiMe(3))(2) yielded the neutral phosphinoenolate-ruthenium(II) compound [RuClPBu(t)[CH=C(OMe)O][CH2C(OMe)=O]-kappa(3)P,O,O}PBu(1)[CH2C(OMe)=O](CH(2)CO(2)Me)-kappa(2)P,O}] 3 which, by cleavage of the Ru-O(ester) bonds, reacted with CO or CNMe to give the corresponding monocarbonyl or bis(isocyanide) complexes [RuCl(CO)PBu(t)[CH=C(OMe)O](CH(2)CO(2)Me)kappa(2)P,O}PBu(t)[CH2C (OMe)=O](CH(2)CO(2)Me)-kappa(2)P,O}] 4 or [RuCl(CNMe)(2)PBu(t)[CH=C(OMe)O](CH(2)CO(2)Me)-kappa(2)P,O}PBu(t) (CH(2)CO(2)Me)(2)-kappa P}] 5 respectively. On treatment with PhNCO compound 3 underwent ail insertion reaction of the isocyanate into the C-H bond of the metal enolate to give the ring-substituted derivative [RuClPBu(t)[C(CONHPh)=C(OMe)O][CH2C(OMe)=O]-kappa(3)P,O,O} PBu(1)[CH2C(OMe)=O](CH(2)CO(2)Me)-kappa(2)P,O}] 6. While compound 3 reacted with water in tetrahydrofuran to yield almost quantitatively the phosphino(monoester)acetate complex [RuClPBu(t)[CH2C(O)O][CH2C(OMe)=O]-kappa(3)P, O,O}PBu(t)[CH2C(OMe)=O](CH(2)CO(2)Me)-kappa(2)P,O}] 7, reaction of 3 with CNBu(t), in the presence of water, yielded the bis(isocyanide) adduct [RuCl(CNBu(t))(2)PBu(t)[CH2C(O)O](CH(2)CO(2)Me)-kappa(2)P,O}PBu(t) (CH(2)CO(2)Me)(2)-kappa-P}] 8. Treatment of 3 with HCl or PhSH reconverted the phosphinoenolate into the phosphinoester moiety with concomitant formation of compounds 1a, 1b and [RuCl(SPh)PBu(t)[CH2C(OMe)=O](CH(2)CO(2)Me)-kappa(2)P,O}(2)] 9, respectively. The molecular structures of la and 3 have been determined by X-ray crystallography.