(6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-formyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester | 54493-81-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-formyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester
• CAS: 54493-81-1
• 化学式: C₃₄H₃₃N₃O₇S
• 分子量: 627.718
• InChiKey: LUNMHJIALRIVDJ-ACXCVDCASA-N

反应信息

• 作为产物：
  描述：

  (6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-hydroxymethyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 在 乙酸酐 作用下， 以 二甲基亚砜 为溶剂， 生成 (6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-formyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester
  参考文献：
  名称：

  Neue ?-Lactam-Antibiotika. �ber die Darstellung und Decarbonylierung von 3-Formylcephem-Verbindungen. Modifikationen von Antibiotica, 12. Mitteilung [1]

  摘要：

  AbstractBenzhydrylic esters of 3‐unsubstituted cephem‐4‐carboxylic acids of types 9 and 10 (Scheme 2) are prepared by decarbonylation of esters of 3‐formylcephem compounds of type 2 with tris‐triphenylphosphine‐rhodium chloride. The preparation of the starting materials 2 and 5, as well as of the nucleus 13 is described.

  DOI：

  10.1002/hlca.19740570715