| 6381-77-7

• 物质功能分类: 原料药 - 维生素类与矿物质类药 - 维生素C类药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• CAS: 6381-77-7
• 化学式: C6H8NaO6
• 分子量: 199.11
• InChiKey: WTTKTIBMFBIUSE-RKJRWTFHSA-N

物化性质

• 熔点：
  154-164°C (decomposes)
• 比旋光度：
  97 º (c=1,DMF)
• 密度：
  1.702[at 20℃]
• 溶解度：
  溶于二甲基亚砜
• LogP：
  -3.29
• 稳定性/保质期：
  在干燥状态下，该物质在空气中较为稳定，但在光照、加热或接触铜、铁等金属离子时容易发生氧化反应。

计算性质

• 辛醇/水分配系数(LogP)：
  -1.79
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• RTECS号：
  MP8910000

SDS

Name:	d-(+)-Isoascorbic acid sodium salt 98% Material Safety Data Sheet
Synonym:	Sodium erythorbat
CAS:	6381-77-7

Section 1 - Chemical Product MSDS Name:d-(+)-Isoascorbic acid sodium salt 98% Material Safety Data Sheet
Synonym:Sodium erythorbat

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
6381-77-7	D-(+)-ISOASCORBIC ACID, SODIUM SALT	98	228-973-9

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid. Wash mouth out with water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

---

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 6381-77-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: 5.5-8 @ 5% aq.sol.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 168 - 170 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 15.3G/100ML WATER (25C)
Specific Gravity/Density:
Molecular Formula: C6H7O6Na
Molecular Weight: 198.11

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, chemically active metals, aluminum, zinc, magnesium,copper.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 6381-77-7: MP8910000 LD50/LC50:
CAS# 6381-77-7: Draize test, rabbit, eye: 100 mg Mild; Oral, rat: LD50 = >5 gm/kg.
Carcinogenicity:
D-(+)-ISOASCORBIC ACID, SODIUM SALT - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 6381-77-7: 0
Canada
CAS# 6381-77-7 is listed on Canada's DSL List.
CAS# 6381-77-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 6381-77-7 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

异抗坏血酸钠的化学性质与用途

一、化学性质

• 外观：白色至黄白色的结晶粉末或颗粒。
• 味道：几乎无味（稍有咸味）。
• 稳定性：干燥状态下对空气相对稳定，但在溶液中遇热、光和微量金属会变质。
• 溶解性：易溶于水（17g/100mL），微溶于乙醇。
• pH值：2%的水溶液pH值范围为5.5至8.0。
• 熔点：200℃以上开始分解。

二、用途

1. 抗氧化剂

   • 用于食品工业，如各类罐头、果酱和冷冻鱼等。
     • 最大使用量为1.0g/kg。
   • 也应用于肉制品中（最大使用量为0.5g/kg，按抗坏血酸计）。
   • 还可用作葡萄酒和果汁饮料类中的抗氧化剂，其最大使用量为0.15g/kg。
   • 适用于啤酒生产过程，其最大允许添加量为0.04g/kg。

2. 防腐助色剂：主要用于食品加工过程中保持色泽及延长保质期。

3. 化妆品抗氧剂：

   • 在化妆品中可以消耗氧气、还原高价金属离子，从而降低氧化反应的发生率。
   • 还能减少由氧化引起的不良产物生成。

4. 其他用途：某些情况下也可作为营养补充剂等使用。

三、生产方法

1. 利用荧光假单胞菌KL005或球状节杆菌KL022发酵D-葡萄糖产生2-酮基-D-葡糖酸（或其钙盐）。

   • 发酵培养液组分包括：葡萄糖(18%)、酵母膏(0.3%)、磷酸二氢钾·3H₂O (0.05%)、磷酸氢二钾(0.05%)、硫酸镁·7H₂O(0.025%)以及CaCO₃(4.5%)。
   • 发酵条件为温度控制在30-35℃之间，发酵周期约30小时。

2. 酸化和脱色：发酵液经加酸（硫酸或草酸）、活性炭处理后进行过滤除杂。

3. 提纯：通过减压浓缩后的清液加入甲醇酯化5小时，并冷冻结晶、离心甩滤获得甲酯，再用碱性甲醇溶液转化得到D-异抗坏血酸钠粗品。

4. 最终精制：溶解于热水中后加活性炭进一步脱色并保温过滤；经冷冻结晶、离心甩干洗涤真空干燥最终制成成品。

5. 母液回收与再利用也是整个生产流程中的重要环节，能提高整体转化效率和产品纯度。

文献信息

• [EN] INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS<br/>[FR] DÉRIVÉS D'INDAZOLYL TRIAZOLE EN TANT QU'INHIBITEURS D'IRAK
  申请人：MERCK SERONO SA

  公开号：WO2012084704A1

  公开（公告）日：2012-06-28

  Compounds of Formula (I) are used for the treatment of inflammation and autoimmune disorders.

  化合物(I)的公式用于治疗炎症和自身免疫性疾病。
• INDAZOLYL TRIAZOL DERIVATIVES
  申请人：Jorand-Lebrun Catherine

  公开号：US20130274241A1

  公开（公告）日：2013-10-17

  Compounds of Formula (I) are used for the treatment of inflammation and autoimmune disorders.

  化合物（I）的公式被用于治疗炎症和自身免疫性疾病。
• PYRIMIDINE PYRAZOLYL DERIVATIVES
  申请人：Ares Trading S.A.

  公开号：US20150141396A1

  公开（公告）日：2015-05-21

  The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases.

  本发明提供了式（I）的化合物，用于治疗癌症、类风湿性关节炎和其他疾病。
• INK-JET RECORDING MEDIUM, AND INK-JET RECORDING METHOD
  申请人：Nippon Paper Industries Co., Ltd.

  公开号：EP2210742A1

  公开（公告）日：2010-07-28

  [PROBLEMS] To provide an ink-jet recording medium which can be imparted with a feeling like an off-set printing paper at a low cost, which can exhibit excellent ink-absorbing properties and scratch resistance in a printed area, and which can achieve good printing quality. [MEANS FOR SOLVING PROBLEMS] The ink-jet recording medium comprises: a base paper mainly composed of a wood pulp; and an ink-receiving layer which is arranged on one or both surfaces of the base paper, and which comprises a binder containing an acrylonitrile butadiene copolymer having a butadiene content of 50 mass% or more and an inorganic pigment. The content of the acrylonitrile butadiene copolymer is 1 to 8 parts by mass (inclusive) relative to 100 parts by mass of the inorganic pigment. The inorganic pigment contains a kaolin at a content of 60 mass % or more, wherein the kaolin contains particles each having a particle diameter of not less than 0.4 µm and less than 4.2 µm as measured by a laser diffraction method at a content of 64% or more in terms of volume-based integrated value. The ink-receiving layer has a surface roughness of 0.6 to 1.4 µm (inclusive) as measured in accordance with JIS P8151 employing a clamping pressure of 1000 kPa and using a hard backing.

  [问题] 提供一种喷墨记录介质，它能以低成本获得类似胶版印刷纸的感觉，在印刷区域 表现出优异的吸墨性能和耐刮擦性能，并能获得良好的印刷质量。[解决问题的方法]喷墨记录介质包括：主要由木浆组成的原纸；以及布置在原纸的一个或两个表面上的受墨层，该受墨层由粘合剂组成，粘合剂含有丁二烯含量大于等于 50%的丙烯腈-丁二烯共聚物和无机颜料。相对于 100 质量份的无机颜料，丙烯腈-丁二烯共聚物的含量为 1 至 8 质量份（含）。无机颜料中的高岭土含量为 60 质量%或以上，其中高岭土中的颗粒通过激光衍射法测得的粒径不小于 0.4 微米且小于 4.2 微米，含量为 64% 或以上（以体积综合值计）。油墨接收层的表面粗糙度为 0.6 至 1.4 微米（包括 1.4 微米），根据 JIS P8151 测量，夹持压力为 1000 千帕，并使用硬衬底。
• INK, IMAGE FORMING METHOD, AND LIQUID DISCHARGING DEVICE
  申请人：Ricoh Company, Ltd.

  公开号：EP3279278A1

  公开（公告）日：2018-02-07

  An ink includes a coloring material, one or more organic solvents, a resin particle including a structure unit having a carboxyl group and a structure unit having an alkoxysilyl group, and water. The one or more organic solvents includes at least one organic solvent having a solubility parameter of 8.96 to less than 11.8. The ink has a dynamic surface tension A of 34.0 mN/m or less for a surface life of 15 msec at 25 degrees C according to maximum bubble pressure technique. The dynamic surface tension A and a static surface tension B of the ink at 25 degrees C satisfy the following relation: 10.0 percent ≤ [(A-B)/(A+B) x 100 ≤ 19.0 percent.

  一种油墨包括着色材料、一种或多种有机溶剂、包括具有羧基的结构单元和具有烷氧基硅基的结构单元的树脂颗粒以及水。一种或多种有机溶剂包括至少一种溶解度参数为 8.96 至小于 11.8 的有机溶剂。根据最大气泡压力技术，在 25 摄氏度、表面寿命为 15 毫秒时，油墨的动态表面张力 A 为 34.0 毫牛顿/米或更低。油墨在 25 摄氏度时的动态表面张力 A 和静态表面张力 B 符合以下关系式：10.0% ≤ [(A-B)/(A+B) x 100 ≤ 19.0%。