dl-2,5-dimercapto-N,N,N',N'-tetramethyladipamide diacetate | 137300-53-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dl-2,5-dimercapto-N,N,N',N'-tetramethyladipamide diacetate
• 英文别名: S-[(2R,5R)-5-acetylsulfanyl-1,6-bis(dimethylamino)-1,6-dioxohexan-2-yl] ethanethioate
• CAS: 137300-53-9
• 化学式: C₁₄H₂₄N₂O₄S₂
• 分子量: 348.488
• InChiKey: AKUXGAIZAIEWTF-VXGBXAGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.24
• 重原子数：
  22.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.76
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  dl-2,5-dimercapto-N,N,N',N'-tetramethyladipamide diacetate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 0.33h， 生成 dl-2,5-dimercapto-N,N,N',N'-tetramethyladipamide
  参考文献：
  名称：

  meso-2,5-Dimercapto-N,N,N',N'-tetramethyladipamide: a readily available, kinetically rapid reagent for the reduction of disulfides in aqueous solution

  摘要：

  meso-2,5-Dimercapto-N,N,N',N'-tetramethyladipamide (meso-DTA) reduces disulfide bonds up to 8 times faster (kinetic) than does dithiothreitol (DTT) in aqueous solution at pH 7.0. meso-DTA is easily synthesized in five steps (39% overall yield) from adipic acid. meso-DTA, which forms a cyclic disulfide, is less reducing than DTT by approximately 56 mV, but is much more reducing than mercaptoethanol.

  DOI：

  10.1021/jo00026a026
• 作为产物：
  描述：

  己二酸 在 氯化亚砜 、 溴 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 9.75h， 生成 dl-2,5-dimercapto-N,N,N',N'-tetramethyladipamide diacetate
  参考文献：
  名称：

  meso-2,5-Dimercapto-N,N,N',N'-tetramethyladipamide: a readily available, kinetically rapid reagent for the reduction of disulfides in aqueous solution

  摘要：

  meso-2,5-Dimercapto-N,N,N',N'-tetramethyladipamide (meso-DTA) reduces disulfide bonds up to 8 times faster (kinetic) than does dithiothreitol (DTT) in aqueous solution at pH 7.0. meso-DTA is easily synthesized in five steps (39% overall yield) from adipic acid. meso-DTA, which forms a cyclic disulfide, is less reducing than DTT by approximately 56 mV, but is much more reducing than mercaptoethanol.

  DOI：

  10.1021/jo00026a026