3-(4-((2S,3S,4S,5R)-5-(3-(2-Benzoyl-4-chloro-phenoxy)-1-methyl-(1E)-propenyl)-3,4-dihydroxy-tetrahydro-furan-2-yloxy)-3-hydroxy-phenyl)-2-methyl-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxy-hexahydro-benzo(1,3)dioxol-5-yl)-(2E)-acrylamide | 270906-33-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(4-((2S,3S,4S,5R)-5-(3-(2-Benzoyl-4-chloro-phenoxy)-1-methyl-(1E)-propenyl)-3,4-dihydroxy-tetrahydro-furan-2-yloxy)-3-hydroxy-phenyl)-2-methyl-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxy-hexahydro-benzo(1,3)dioxol-5-yl)-(2E)-acrylamide
• 英文别名: (E)-N-[(3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxy-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxol-5-yl]-3-[4-[(2S,3S,4S,5R)-5-[(E)-4-(2-benzoyl-4-chlorophenoxy)but-2-en-2-yl]-3,4-dihydroxyoxolan-2-yl]oxy-3-hydroxyphenyl]-2-methylprop-2-enamide
• CAS: 270906-33-7
• 化学式: C₃₈H₄₀ClNO₁₃
• 分子量: 754.188
• InChiKey: ZWEHQMHUCWVQOE-ANZPPZJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  53
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  214
• 氢给体数：
  7
• 氢受体数：
  13

文献信息

• HYGROMYCIN A DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Pfizer Products Inc.

  公开号：EP1135400A1

  公开（公告）日：2001-09-26
• US6245745B1
  申请人：——

  公开号：US6245745B1

  公开（公告）日：2001-06-12
• [EN] HYGROMYCIN A DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES D'HYGROMYCINE A COMME AGENTS ANTIBACTERIENS
  申请人：PFIZER PROD INC

  公开号：WO2000032616A1

  公开（公告）日：2000-06-08

  This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein R?1, R2, R3, X1 and X2¿ are as defined herein. The compounds of formula (1) are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) , methods of treating bacterial and protozoal infections by administering the compounds of formula (1) , and methods of preparing certain compounds of formula (1) .