3-(6-chloro-2-phenyl-4H-chromen-4-yl)-2-methyl-1H-indole | 1575402-57-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(6-chloro-2-phenyl-4H-chromen-4-yl)-2-methyl-1H-indole
• 英文别名: 6-chloro-4-(2-methylindol-3-yl)-2-phenyl-4H-chromene
• CAS: 1575402-57-1
• 化学式: C₂₄H₁₈ClNO
• 分子量: 371.866
• InChiKey: SZCNUQBPRCFYIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  25
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基吲哚 、 3-(5-chloro-2-hydroxyphenyl)-1-phenylprop-2-en-1-one 在 Amberlyst-15 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以77%的产率得到3-(6-chloro-2-phenyl-4H-chromen-4-yl)-2-methyl-1H-indole
  参考文献：
  名称：

  A facile synthesis of 2-aryl-4-(indol-3-yl)-4H-chromenes using amberlyst-15 as an efficient recyclable heterogeneous catalyst

  摘要：

  Starting from 2-hydroxychalcones and indoles, a facile synthesis of 2-aryl-4-(indol-3-yl)-4H-chromenes has been achieved by use of amberlyst-15, a sulfonated polystyrene resin, as a recyclable heterogeneous catalyst. The methodology involves a domino sequence of Michael addition, cyclization, and dehydration.

  DOI：

  10.1007/s00706-014-1401-8

文献信息

• 2-Methylindole as an Indicative Nucleophile for Developing a Three-Component Reaction of Aldehyde with Two Different Nucleophiles
  作者：Dan Jiang、Xiaojuan Pan、Minghao Li、Yanlong Gu

  DOI：10.1021/co500010x

  日期：2014.6.9

  2-Methylindole was used as an indicative nucleophile for rapid screening of MCRs of aldehydes with two different nucleophiles. By removal of some samples that have characteristic color associated with the generation of di(indolyOmethane derivatives the difficulties encountered in the product analysis were alleviated significantly.