3-碘-N-(3,4-二碘苯基)-2-羟基苯甲酰胺 | 14437-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-碘-N-(3,4-二碘苯基)-2-羟基苯甲酰胺
• 英文名称: 3,4',5-Triiodsalicylanilid
• 英文别名: 2-hydroxy-3,5-diiodo-N-(4-iodo-phenyl)-benzamide；2-hydroxy-3,5-diiodo-N-(4-iodophenyl)benzamide
• CAS: 14437-45-7
• 化学式: C₁₃H₈I₃NO₂
• 分子量: 590.926
• InChiKey: QOUSLZBAJRLUGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  3-碘-N-(3,4-二碘苯基)-2-羟基苯甲酰胺 、 丁炔二酸二甲酯 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 6,8-diiodo-3-(4-iodo-phenyl)-2-methoxycarbonylmethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  一类新的1,3-苯并恶嗪酮类化合物作为潜在的中枢神经系统制剂。

  摘要：

  DOI：

  10.1021/jm00299a047
• 作为产物：
  描述：

  3,5-二碘水杨酸 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 3-碘-N-(3,4-二碘苯基)-2-羟基苯甲酰胺
  参考文献：
  名称：

  Design, Synthesis, and Biological Activities of Closantel Analogues: Structural Promiscuity and Its Impact on Onchocerca volvulus

  摘要：

  Onchocerciasis, or river blindness, is a neglected tropical disease that affects more than 37 million people worldwide, primarily in Africa and Central and South America. We have disclosed evidence that the larval-stage-specific chitinase, OvCHT1, may be a potential biological target for affecting nematode development. On the basis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly specific OvCHT1 inhibitor. Originally, closantel's anthelmintic mode of action was believed to rely solely on its role as a proton ionophore; thus, the impact of each of its biological activities on O. volvulus L3 molting was investigated. Structure activity relationship studies on an active closantel fragment are detailed, and remarkably, by use of a simple salicylanilide scaffold, compounds acting only as protonophores or chitinase inhibitors were identified. From these data, unexpected synergistic protonophore and chitinase inhibition activities have also been found to be critical for molting in O. volvulus L3 larvae.

  DOI：

  10.1021/jm200364n

文献信息

• PIPETTE TIPS
  申请人：Biotix, Inc.

  公开号：EP3831489A1

  公开（公告）日：2021-06-09

  The present invention relates to a pipette tip comprising a proximal region and a distal region, wherein the proximal region comprises an exterior surface and an annular flange at the proximal terminus of the proximal region, the proximal region comprises a first set of axially oriented ribs and a second set of axially oriented ribs, the ribs of the first set and the second set are circumferentially spaced and alternately spaced around the exterior surface of the proximal region, and ribs of the first set have a maximum thickness greater than the maximum thickness of ribs of the second set.

  本发明涉及一种移液器吸头，包括一个近端区域和一个远端区域，其中近端区域包括一个外表面和一个位于近端区域近端末端的环形凸缘，近端区域包括第一组轴向定向的肋条和第二组轴向定向的肋条，第一组和第二组肋条在近端区域的外表面周向间隔并交替间隔，第一组肋条的最大厚度大于第二组肋条的最大厚度。
• Antimicrobial contact lens case
  申请人：——

  公开号：US20030176530A1

  公开（公告）日：2003-09-18

  A contact lens case having antimicrobial characteristics composed of a polymeric material having a plurality of amorphous zones. An antimicrobial agent is incorporated into said amorphous zones of the polymeric material of said body. The antimicrobial agent exhibits controlled migration through the amorphous zones of the polymeric material of said body. In this manner, the surface of the lens case is consistently saturated with an antimicrobial agent.

  一种具有抗菌特性的隐形眼镜盒，由具有多个无定形区的聚合物材料组成。抗菌剂被掺入所述主体聚合物材料的无定形区中。抗菌剂通过所述主体聚合物材料的无定形区进行受控迁移。这样，镜片外壳的表面就会持续饱和抗菌剂。
• Salicylamide--acetylenedicarboxylate reactions as a route to benzoxazinones
  作者：Ned D. Heindel、Lee A. Schaeffer

  DOI：10.1021/jo00832a089

  日期：1970.7
• ANTIMICROBIAL CONTACT LENS CASE
  申请人：Novartis AG

  公开号：EP1458419B1

  公开（公告）日：2005-05-04
• Anti-microbial paper products having a substituted 1,2-dihydroquinoline
  申请人：Abou-Nemeh Ibrahim

  公开号：US20070089847A1

  公开（公告）日：2007-04-26

  The present invention generally provides anti-microbial paper products, compositions comprising anti-microbial paper products, processes for producing anti-microbial paper products, and methods of inhibiting microbial growth or replication in paper products.