ethyl 2-[(3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl]-4-(5-{[2-(2-oxopyrrolidin-1-yl)ethyl]amino}pyrazin-2-yl)-1,3-thiazole-5-carboxylate | 1229572-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-[(3S,4R)-4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl]-4-(5-{[2-(2-oxopyrrolidin-1-yl)ethyl]amino}pyrazin-2-yl)-1,3-thiazole-5-carboxylate
• 英文别名: ethyl 2-[(3S,4R)-4-[(3,4-dichloro-5-methyl-1H-pyrrole-2-carbonyl)amino]-3-methoxypiperidin-1-yl]-4-[5-[2-(2-oxopyrrolidin-1-yl)ethylamino]pyrazin-2-yl]-1,3-thiazole-5-carboxylate
• CAS: 1229572-30-8
• 化学式: C₂₈H₃₄Cl₂N₈O₅S
• 分子量: 665.601
• InChiKey: GFCJNWPDCPYJJV-AEFFLSMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  183
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• PIPERIDINE COMPOUNDS AND USES THEREOF - 596
  申请人：BASARAB Gregory

  公开号：US20100173909A1

  公开（公告）日：2010-07-08

  Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  本文描述了化学式(I)的化合物及其药学上可接受的盐。同时还描述了它们的制备方法、含有它们的药物组合物、作为药物的用途以及在治疗细菌感染方面的用途。
• 2-(PIPERIDIN-1-YL)-4-HETEROCYCLYL-THIAZOLE-5-CARBOXYLIC ACID DERIVATIVES AGAINST BACTERIAL INFECTIONS
  申请人：BASARAB Gregory

  公开号：US20120028979A1

  公开（公告）日：2012-02-02

  Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  本文描述了公式(I)的化合物及其药学上可接受的盐。还描述了制备它们的过程、包含它们的药物组合物、它们作为药物的用途以及它们在治疗细菌感染中的应用。
• Selective estrogen receptor modulators containing a phenylsulfonyl group
  申请人：Eli Lilly & Company

  公开号：EP1782810A2

  公开（公告）日：2007-05-09

  The present invention relates to a selective estrogen receptor modulator of formula I: or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.

  本发明涉及一种式 I 的选择性雌激素受体调节剂： 或其药用酸加成盐；可用于治疗子宫内膜异位症和/或子宫白肌瘤/卵巢白肌瘤。
• SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP
  申请人：ELI LILLY AND COMPANY

  公开号：EP1530470B1

  公开（公告）日：2009-06-10
• US8071605B2
  申请人：——

  公开号：US8071605B2

  公开（公告）日：2011-12-06