2-hydroxy-5-(1(2)H-tetrazol-5-yl)-benzoic acid | 68535-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-hydroxy-5-(1(2)H-tetrazol-5-yl)-benzoic acid
• 英文别名: 2-hydroxy-5-(2H-1,2,3,4-tetrazol-5-yl)benzoic acid；2-hydroxy-5-(2H-tetrazol-5-yl)benzoic acid
• CAS: 68535-39-7
• 化学式: C₈H₆N₄O₃
• 分子量: 206.161
• InChiKey: ZFXPNVWAVFNWNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-hydroxy-5-(1(2)H-tetrazol-5-yl)-benzoic acid ethyl ester 、 氢氧化钾 生成 2-hydroxy-5-(1(2)H-tetrazol-5-yl)-benzoic acid
  参考文献：
  名称：

  JONES H.; FORDICE M. W.; GREENWALD R. B.; HANNAH J.; JACOBS A.; RUYLE W. +, J. MED. CHEM., 1978, 21, NO 11, 1100-1104

  摘要：

  DOI：

文献信息

• REAL-TIME METHOD FOR THE DETECTION OF VIABLE MICRO-ORGANISMS
  申请人：Nederlandse Organisatie voor Toegepast -Natuurwetenschappelijk Onderzoek TNO

  公开号：EP2232243A1

  公开（公告）日：2010-09-29
• [EN] REAL-TIME METHOD FOR THE DETECTION OF VIABLE MICRO-ORGANISMS<br/>[FR] PROCÉDÉ EN TEMPS RÉEL POUR LA DÉTECTION DE MICRO-ORGANISMES VIABLES
  申请人：TNO

  公开号：WO2009082218A1

  公开（公告）日：2009-07-02

  The invention relates to a method for real-time detection of viable microorganisms comprising: a. addition of a cell-permeable, phototautomeric compound to a micro-organism or other living cell; and b. measuring the fluorescent emission of said phototautomeric compound. Preferably the phototautomeric compound is salicylic acid, 2-hydroxy-l-naphtoic acid or 1- hydroxy-2-naphtoic acid. Further, the assay can be used to assess the antibiotic effect of a test compound. This test can be used as a high- throughput screening for compounds with antibiotic activity. Also part of the invention is the use of a cell permeable phototautomeric compound in a method for determining the viability of micro-organisms and for assessing the antibiotic effect of a test compound.
• [EN] APPARATUS FOR DETECTING VIABLE MICROORGANISMS OR SPORES IN A SAMPLE AND USE THEREOF.<br/>[FR] APPAREIL POUR LA DETECTION DE MICROORGANISMES OU SPORES VIABLES DANS UN ECHANTILLON ET SON UTILISATION
  申请人：TNO

  公开号：WO2010151131A2

  公开（公告）日：2010-12-29

  The present invention relates to the field of microbiology, more particular to an apparatus for detecting viable microorganisms or spores in a sample. Provided is an apparatus comprising an inlet for said sample, a sample immobilization area, a container comprising a composition comprising a phototautomeric compound, a light source and a detection unit. Also provided are the use of such an apparatus for detecting at least one viable microorganism in a sample, and the use of such an apparatus for detecting at least one viable spore in a sample.