4-(4-methoxybenzyl)-2-phenyloxazolo[4,5-b]pyridin-5(4H)-one | 1017553-52-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-methoxybenzyl)-2-phenyloxazolo[4,5-b]pyridin-5(4H)-one
• CAS: 1017553-52-4
• 化学式: C₂₀H₁₆N₂O₃
• 分子量: 332.359
• InChiKey: UKHVGGYTURWCQG-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  (+/-)-(3aR,7aS)-4-(4-methoxybenzyl)-3a,4,7,7a-tetrahydro-2-phenyloxazolo[b]pyridin-5(6H)-one 在 manganese(IV) oxide 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以62%的产率得到4-(4-methoxybenzyl)-2-phenyloxazolo[4,5-b]pyridin-5(4H)-one
  参考文献：
  名称：

  Diastereoselective Ritter Reactions of Chiral Cyclic N-Acyliminium Ions:  Synthesis of Pyrido- and Pyrrolo[2,3-d]oxazoles and 4-Hydroxy-5-N-acylaminopyrrolidines and 5-Hydroxy-6-N-acylaminopiperidines

  摘要：

  Pyrido- and pyrrolo[2,3-d]oxazoles can be conveniently prepared in high yield from the Ritter reaction of nitriles and in situ generated chiral cyclic N-acyliminium ions. cis-4-Hydroxy-5-acylaminopyrrolidines and cis-5-hydroxy-6-acylaminopiperidines can be readily obtained by acid hydrolysis of these bicyclic heterocyclic compounds, respectively.

  DOI：

  10.1021/jo800007g