| 903903-41-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 903903-41-3
• 化学式: C₃₂H₅₀O₅Si
• 分子量: 542.832
• InChiKey: DEOFQEBMGPJDHV-YYKHYQNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.83
• 重原子数：
  38.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  69.67
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 三氟化硼乙醚 作用下， 以 氘代氯仿 为溶剂， 生成 (S)-8-Methyl-7-oxo-4-vinyl-1,5,6,7-tetrahydro-2H-naphthalene-4a-carboxylic acid 6-isopropyl-2-(1-methyl-2-oxo-ethyl)-tetrahydro-pyran-2-ylmethyl ester 、 (S)-8-Methyl-7-oxo-4-vinyl-1,5,6,7-tetrahydro-2H-naphthalene-4a-carboxylic acid 6-hydroxy-7-methyl-2-[1-methyl-2-oxo-eth-(Z)-ylidene]-octyl ester 、 (Z)-3-((R)-3,7-Dimethyl-1,8-dioxo-3,5,6,8,9,10-hexahydro-2-oxa-cyclopenta[d]naphthalen-3-ylmethyl)-2,8-dimethyl-7-oxo-non-2-enal
  参考文献：
  名称：

  A synthetic approach to enfumafungin

  摘要：

  The stereospecific synthesis of the dienophile subunits 5 was achieved from the butenolide 6. Ester 19 was obtained in 67% overall yield (2 steps), with no intermediate purification, by a sodium chlorite oxidation of the corresponding aldehyde in buffered conditions, followed immediately after extraction, by a Mitsunobu reaction of the relatively labile acid 3 with alcohol 13. The synthesis of the alpha,beta-unsaturated aldehydes 22 and 23 is also reported. Tentative IMDA reactions of 22 and 23 were examined in thermal conditions, or with a Lewis acid catalysis, and results are reported herein. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.113
• 作为产物：
  描述：

  4-(tert-Butyldimethylsilyloxy)-5-methyl-1-hexene 在 吡啶 、 palladium diacetate 、 potassium phosphate 、 lithium aluminium tetrahydride 、 正丁基锂 、 戴斯-马丁氧化剂 、 氟化氢吡啶 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 吡啶 、 正己烷 、 二氯甲烷 、 甲苯 为溶剂， 反应 14.83h， 生成
  参考文献：
  名称：

  A synthetic approach to enfumafungin

  摘要：

  The stereospecific synthesis of the dienophile subunits 5 was achieved from the butenolide 6. Ester 19 was obtained in 67% overall yield (2 steps), with no intermediate purification, by a sodium chlorite oxidation of the corresponding aldehyde in buffered conditions, followed immediately after extraction, by a Mitsunobu reaction of the relatively labile acid 3 with alcohol 13. The synthesis of the alpha,beta-unsaturated aldehydes 22 and 23 is also reported. Tentative IMDA reactions of 22 and 23 were examined in thermal conditions, or with a Lewis acid catalysis, and results are reported herein. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.04.113