ethyl 5-((6-phenylbicyclo[3.1.0]hexan-6-yl)methylamino)-1-p-tolyl-1H-1,2,4-triazole-3-carboxylate | 1329682-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 5-((6-phenylbicyclo[3.1.0]hexan-6-yl)methylamino)-1-p-tolyl-1H-1,2,4-triazole-3-carboxylate
• CAS: 1329682-22-5
• 化学式: C₂₅H₂₈N₄O₂
• 分子量: 416.523
• InChiKey: FHFDWQJCCJGUGC-GQEURGSBSA-N

反应信息

• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 ethyl 5-((6-phenylbicyclo[3.1.0]hexan-6-yl)methylamino)-1-p-tolyl-1H-1,2,4-triazole-3-carboxylate 、 ethyl 5-((6-phenylbicyclo[3.1.0]hexan-6-yl)methylamino)-1-p-tolyl-1H-1,2,4-triazole-3-carboxylate
  参考文献：
  名称：

  Reactivity of N-(1,2,4-Triazolyl)-Substituted 1,2,3-Triazoles

  摘要：

  Synthetically useful rhodium(II) carbenes were obtained from N-(1,2,4-triazolyl)-substituted 1,2,3-triazoles and Rh(II) carboxylates. The electron-withdrawing 1,2,4-triazolyl group reveals the heretofore unknown reactivity of nonsulfonyl 1,2,3-triazoles, which exhibit the reactivity of diazo compounds. The resulting carbenes provide ready asymmetric access to secondary homoaminocyclopropanes (80-95% ee, dr >20:1) via reactions with olefins and also engage in efficient transannulation reactions with nitriles.

  DOI：

  10.1021/ol201949h