5-(2H-tetrazol-5-yl)benzene-1,3-diol | 1383535-23-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2H-tetrazol-5-yl)benzene-1,3-diol
• CAS: 1383535-23-6
• 化学式: C₇H₆N₄O₂
• 分子量: 178.15
• InChiKey: STZIPIVZRWVCLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-二羟基苯甲腈 在 三正丁基叠氮化锡 、 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以191.4 mg的产率得到5-(2H-tetrazol-5-yl)benzene-1,3-diol
  参考文献：
  名称：

  Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects

  摘要：

  Following the characterization of the lactate receptor (GPR81), a focused screening effort afforded 3-hydroxybenzoic acid 1 as a weak agonist of both GPR81 and GPR109a (niacin receptor). An examination of structurally similar arylhydroxy acids led to the identification of 3-chloro-5-hydroxybenzoic acid 2, a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity.

  DOI：

  10.1021/ml3000676

文献信息

• Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects
  作者：Curt A. Dvorak、Changlu Liu、Jonathan Shelton、Chester Kuei、Steven W. Sutton、Timothy W. Lovenberg、Nicholas I. Carruthers

  DOI：10.1021/ml3000676

  日期：2012.8.9

  Following the characterization of the lactate receptor (GPR81), a focused screening effort afforded 3-hydroxybenzoic acid 1 as a weak agonist of both GPR81 and GPR109a (niacin receptor). An examination of structurally similar arylhydroxy acids led to the identification of 3-chloro-5-hydroxybenzoic acid 2, a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity.