MCMG2-Ad-DOPE | 1384865-25-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: MCMG2-Ad-DOPE
• CAS: 1384865-25-1
• 化学式: C₈₅H₁₄₄N₁₅O₃₀P
• 分子量: 1887.13
• InChiKey: PPRXHSLSJCUITI-UUPQPXBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.34
• 重原子数：
  131.0
• 可旋转键数：
  79.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  611.82
• 氢给体数：
  12.0
• 氢受体数：
  30.0

反应信息

• 作为反应物：
  描述：

  GalNAcα1-3(Fucα1-2)Galβ-O(CH2)3NCO(CH2)4COO(p-C6H4NO2) 、 MCMG2-Ad-DOPE 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以85%的产率得到FSL-A(tri)-MCMG2
  参考文献：
  名称：

  Toward creating cell membrane glyco-landscapes with glycan lipid constructs

  摘要：

  Synthetic glycolipid-like constructs dispersible in biological media and capable of incorporating into cell membranes have the ability to create novel artificial glyco-landscapes on living cells. Using a variety of different glycans ranging from disaccharides to polysaccharides, together with different lengths and high hydrophilicity spacers, we created a series of synthetic glycolipid-like constructs. Contacting these constructs with live cells gave modified cells with controlled glycan density and/or altered biological function. The ability to also use these constructs as solutions to inhibit antibodies, toxins, and virions extends the potential diagnostic and therapeutic uses for these synthetic glycolipid-like constructs. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2012.03.044
• 作为产物：
  描述：

  DOPE-Ad-ONSu 、 MCMG2 在 三乙胺 作用下， 以 吡啶 、 水 、 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以26%的产率得到MCMG2-Ad-DOPE
  参考文献：
  名称：

  Toward creating cell membrane glyco-landscapes with glycan lipid constructs

  摘要：

  Synthetic glycolipid-like constructs dispersible in biological media and capable of incorporating into cell membranes have the ability to create novel artificial glyco-landscapes on living cells. Using a variety of different glycans ranging from disaccharides to polysaccharides, together with different lengths and high hydrophilicity spacers, we created a series of synthetic glycolipid-like constructs. Contacting these constructs with live cells gave modified cells with controlled glycan density and/or altered biological function. The ability to also use these constructs as solutions to inhibit antibodies, toxins, and virions extends the potential diagnostic and therapeutic uses for these synthetic glycolipid-like constructs. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2012.03.044