5-cyano-N2-{3-[1-N-isopropyl-(tetrazol-5-yl)]}phenyl-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-2,4-pyrimidinediamine | 1239594-18-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-cyano-N2-{3-[1-N-isopropyl-(tetrazol-5-yl)]}phenyl-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-2,4-pyrimidinediamine
• 英文别名: 4-[(1,2,2,6,6-Pentamethylpiperidin-4-yl)amino]-2-[3-(1-propan-2-yltetrazol-5-yl)anilino]pyrimidine-5-carbonitrile
• CAS: 1239594-18-3
• 化学式: C₂₅H₃₄N₁₀
• 分子量: 474.612
• InChiKey: IZNFVHRUNHPMTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2389373A1

  公开（公告）日：2011-11-30
• [EN] DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES<br/>[FR] DÉRIVÉS DE N2-(3-PYRIDIL OU PHÉNYL)-N4-(4-PIPÉRIDYL)-2,4-PYRIMIDINEDIAMINE UTILES DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES, AUTO-IMMUNES OU PROLIFÉRATIVES
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2010090875A1

  公开（公告）日：2010-08-12

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.