N3-benzoyl-2'-O-methoxycarbonylmethyluridine | 1207847-51-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: N3-benzoyl-2'-O-methoxycarbonylmethyluridine
• CAS: 1207847-51-5
• 化学式: C₁₉H₂₀N₂O₉
• 分子量: 420.376
• InChiKey: PYZQLLHPXMPGQA-HALQFCHDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.49
• 重原子数：
  30.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  146.29
• 氢给体数：
  2.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  N3-benzoyl-2'-O-methoxycarbonylmethyluridine 、 4,4'-双甲氧基三苯甲基氯 在 吡啶 作用下， 反应 17.0h， 以89%的产率得到N3-benzoyl-5'-O-dimethoxytrityl-2'-O-methoxycarbonylmethyluridine
  参考文献：
  名称：

  Synthesis and Properties of Oligodeoxyribonucleotides Bearing a Polyamino Group at the 2′ Position via 2′-O-Carbamoylmethyl and 2′-S-Carbamoylmethyl groups

  摘要：

  An oligodeoxyribonucleotide containing 2'-O-methoxycarbonylmethyluridine was synthesized and converted into several 2'-modified oligodeoxyribonucleotides by a postsynthetic modification method. Using this method, oligodeoxyribonucleotides bearing a polyamine at the 2' Position were easily prepared, which could form duplexes with either complementary DNA or RNA.

  DOI：

  10.1080/15257770903307185
• 作为产物：
  描述：

  N3-benzoyl-2'-O-methoxycarbonylmethyl-1',3'-O-(1,1,3,3-tetraisopropyldisiloxane)uridine 在 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 为溶剂， 以62%的产率得到N3-benzoyl-2'-O-methoxycarbonylmethyluridine
  参考文献：
  名称：

  Synthesis and Properties of Oligodeoxyribonucleotides Bearing a Polyamino Group at the 2′ Position via 2′-O-Carbamoylmethyl and 2′-S-Carbamoylmethyl groups

  摘要：

  An oligodeoxyribonucleotide containing 2'-O-methoxycarbonylmethyluridine was synthesized and converted into several 2'-modified oligodeoxyribonucleotides by a postsynthetic modification method. Using this method, oligodeoxyribonucleotides bearing a polyamine at the 2' Position were easily prepared, which could form duplexes with either complementary DNA or RNA.

  DOI：

  10.1080/15257770903307185