| 1017610-19-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1017610-19-3
• 化学式: C₂₀H₃₅N₂O₈P
• 分子量: 462.48
• InChiKey: YXKJNFDUJCXTGV-ZENAZSQFSA-N

反应信息

• 作为反应物：
  描述：

  在 全氟丁基磺酰氟 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase

  摘要：

  A series of N-3-substituted thymine acyclic nucleoside phosphonates bearing a number of ( phosphonomethoxy) alkyl groups were synthesized and investigated for their ability to inhibit the human thymidine phosphorylase expressed in V79 Chinese hamster cells, as well as thymidine phosphorylase from SD-lymphoma, Escherichia coli and human placenta. In comparison to N-1- substituted analogues which possess a considerable inhibitory activity towards thymidine phosphorylase from SD-lymphoma, the results showed a marginal inhibitory effect of these compounds. None of the presented N-3-substituted derivatives possess a significant cytostatic activity. (c) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.01.006
• 作为产物：
  描述：

  在 palladium on activated charcoal 氢气 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase

  摘要：

  A series of N-3-substituted thymine acyclic nucleoside phosphonates bearing a number of ( phosphonomethoxy) alkyl groups were synthesized and investigated for their ability to inhibit the human thymidine phosphorylase expressed in V79 Chinese hamster cells, as well as thymidine phosphorylase from SD-lymphoma, Escherichia coli and human placenta. In comparison to N-1- substituted analogues which possess a considerable inhibitory activity towards thymidine phosphorylase from SD-lymphoma, the results showed a marginal inhibitory effect of these compounds. None of the presented N-3-substituted derivatives possess a significant cytostatic activity. (c) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.01.006