5-(4-(benzyloxy)phenyl)-2-(4-chlorophenyl)-6-[(E)-3-(4-chlorophenyl)acryloyl]-7-methylchroman-4-one | 1365935-44-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5-(4-(benzyloxy)phenyl)-2-(4-chlorophenyl)-6-[(E)-3-(4-chlorophenyl)acryloyl]-7-methylchroman-4-one
• CAS: 1365935-44-9
• 化学式: C₃₈H₂₈Cl₂O₄
• 分子量: 619.544
• InChiKey: XWFYAIRHMRGCRA-AWQFTUOYSA-N

反应信息

• 作为产物：
  描述：

  3-(4-chlorophenyl)-1-[3-[3-(4-chlorophenyl)prop-2-enoyl]-4-hydroxy-6-methyl-2-(4-phenylmethoxyphenyl)phenyl]prop-2-en-1-one 在 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 以93%的产率得到5-(4-(benzyloxy)phenyl)-2-(4-chlorophenyl)-6-[(E)-3-(4-chlorophenyl)acryloyl]-7-methylchroman-4-one
  参考文献：
  名称：

  Synthesis of 5-aryl-6-cinnamoyl-7-methyl-flavanones as novel antioxidants and antihyperlipidemics

  摘要：

  An economical and efficient one-pot synthesis of a series of novel 5-aryl-6-cinnamoyl-7-methyl-flavanones has been developed by simple refluxing of cinnamoyl chalcones with NaOAc in aqueous ethanol in quantitative yields. These flavanones were screened for their in vitro antioxidant and in vivo antidyslipidemic activities. Among 24 compounds screened, four compounds 28, 29, 30, and 48 showed significant antidyslipidemic activities. However, out of all the compounds, only compound 28 exhibited significant antioxidant activity and other compounds showed moderate antioxidant activities.

  DOI：

  10.3109/14756366.2011.585134