aminophenylthioacetic acid | 79962-06-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: aminophenylthioacetic acid
• 英文别名: 2-amino-2-phenylethanethioic S-acid
• CAS: 79962-06-4
• 化学式: C₈H₉NOS
• 分子量: 167.232
• InChiKey: HUPFFHLRZXIFMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-2-苯基乙酸 在 2,6-二甲基吡啶 、 光气 、 硫化氢 作用下， 生成 aminophenylthioacetic acid
  参考文献：
  名称：

  Cricchio; Berti; Cietto, European Journal of Medicinal Chemistry, 1981, vol. 16, # 4, p. 301 - 306

  摘要：

  DOI：

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AS HIV PROTEASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE LA PROTÉASE DU VIH
  申请人：MERCK SHARP & DOHME

  公开号：WO2018106519A1

  公开（公告）日：2018-06-14

  The present invention is directed to compounds of Formula (I), pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

  本发明涉及式(I)的化合物，包括相同的药物组合物，以及它们在抑制HIV蛋白酶、抑制HIV复制、预防HIV感染、治疗HIV感染以及预防、治疗和延缓艾滋病的发病或进展中的用途。
• 2-Substituted phenyl-4,5,6,7-tetrahydro-2H-iso-indole-1,3-diones, and
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04684397A1

  公开（公告）日：1987-08-04

  A 2-substituted phenyl-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione of the formula: ##STR1## wherein X is a chlorine atom or a bromine atom and R is a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.2 -C.sub.6 haloalkyl group, a C.sub.1 -C.sub.4 alkoxy(C.sub.1 -C.sub.4)alkyl group, a C.sub.1 -C.sub.6 alkoxycarbonyl(C.sub.1 -C.sub.3)alkyl group or a phenyl group, which is useful as a herbicide.

  一种公式为：##STR1##的2-取代苯基-4,5,6,7-四氢-2H-异吲哚-1,3-二酮，其中X为氯原子或溴原子，R为C.sub.1-C.sub.6烷基，C.sub.3-C.sub.7环烷基，C.sub.3-C.sub.6烯基，C.sub.3-C.sub.6炔基，C.sub.2-C.sub.6卤代烷基，C.sub.1-C.sub.4烷氧基(C.sub.1-C.sub.4)烷基，C.sub.1-C.sub.6烷氧基羧酸(C.sub.1-C.sub.3)烷基或苯基，其作为除草剂有用。
• 2-substituted phenyl-4,5,6,7,-tetrahydro-2H-indole-1,3,-diones, and
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04709049A1

  公开（公告）日：1987-11-24

  3-Amino-4-fluoro-6-halophenylthioacetic acids of the formula: ##STR1## and 5-substituted acetanilides of the formula: ##STR2## , which are intermediary compounds for the synthesis of herbicidally effective 2-substituted phenyl-4,5,6,7-tetrahydro-2H-isoindole-1,3-diones of the formula: ##STR3## through the corresponding acid of the formula: ##STR4## (wherein X is a chlorine atom or a bromine atom, R is a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.2 -C.sub.6 haloalkyl group, a C.sub.1 -C.sub.4 alkoxy(C.sub.1 -C.sub.4)alkyl group, a C.sub.1 -C.sub.6 alkoxycarbonyl(C.sub.1 -C.sub.3)alkyl group or a phenyl group and Z is --NO.sub.2, --NH.sub.2, --SCH.sub.2 COOH, --SO.sub.2 Cl, --SO.sub.3 H or --SH).

  公式：3-氨基-4-氟-6-卤代苯硫乙酸（如下式）和5-取代苯乙酰胺（如下式），是合成除草有效的2-取代苯基-4,5,6,7-四氢-2H-异吲哚-1,3-二酮（如下式）的中间体化合物，其可通过相应的酸（如下式）合成（其中X为氯原子或溴原子，R为C1-C6烷基、C3-C7环烷基、C3-C6烯基、C3-C6炔基、C2-C6卤代烷基、C1-C4烷氧基（C1-C4）烷基、C1-C6烷氧羰基（C1-C3）烷基或苯基，Z为--NO2、--NH2、--SCH2COOH、--SO2Cl、--SO3H或--SH）。
• Substituted-di-t-butylphenols
  申请人：RIKER LABORATORIES, INC.

  公开号：EP0212848A2

  公开（公告）日：1987-03-04

  Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substitutent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents. Pharmaceutical compositions containing and pharmacological methods of using such compounds are also disclosed, as are synthetic intermediates for preparing such compounds. Certain of the synthetic intermediates also exhibit useful antiallergic activity.

  2,6-二对丁基苯酚在 4 位上被苯胺基取代的新型化合物是有用的抗过敏剂，苯胺基被羧基取代基、四唑基取代基或 N-甲基四唑基取代基取代。此外，还公开了含有此类化合物的药物组合物和使用此类化合物的药理方法，以及制备此类化合物的合成中间体。某些合成中间体也显示出有用的抗过敏活性。
• Mixed mode ligands
  申请人：Bio-Rad Laboratories, Inc.

  公开号：US10583429B2

  公开（公告）日：2020-03-10

  The present disclosure is directed to mixed mode chromatography media comprising a ligand directly attached to a solid support. In some aspects, the ligand has a chemical formula of The mixed mode chromatography media is useful for binding and purifying proteins from a solution.

  本公开涉及混合模式色谱介质，该介质包含直接连接到固体支持物上的配体。在某些方面，配体的化学式为 混合模式色谱介质可用于从溶液中结合和纯化蛋白质。