(1-cyclohexanone-4-yl)-[5-methyl-2-(pyridin-2-yl)-1H-indol-7-yl]amine | 1120332-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (1-cyclohexanone-4-yl)-[5-methyl-2-(pyridin-2-yl)-1H-indol-7-yl]amine
• 英文别名: (1-cyclohexanon-4-yl)-[5-methyl-2-(pyridin-2-yl)-1H-indol-7-yl]amine；(1-oxocyclohexan-4-yl)-[5-methyl-2-(pyridin-2-yl)-1H-indol-7-yl]-amine；4-(5-methyl-2-pyridine-2-yl-1H-indole-7-ylamino)-cyclohexanone；4-(5-methyl-2-pyridin-2-yl-1H-indol-7-ylamino)-cyclohexanone；4-[(5-methyl-2-pyridin-2-yl-1H-indol-7-yl)amino]cyclohexan-1-one
• CAS: 1120332-12-8
• 化学式: C₂₀H₂₁N₃O
• 分子量: 319.406
• InChiKey: IAYWZXWADWKNEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (1,4-dioxa[4.5]dec-8-yl)-[5-methyl-2-(pyridin-2-yl)-1H-indol-7-yl]amine 在 盐酸 水 、 丙酮 作用下， 反应 8.0h， 以23%的产率得到(1-cyclohexanone-4-yl)-[5-methyl-2-(pyridin-2-yl)-1H-indol-7-yl]amine
  参考文献：
  名称：

  [EN] INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS
  [FR] COMPOSÉS D'INDOLE ET D'INDAZOLE EN TANT QU'INHIBITEURS DE NÉCROSE CELLULAIRE

  摘要：

  本发明涉及吲哚或吲唑化合物，其药用盐或异构体，可用于预防或治疗细胞坏死和与坏死相关的疾病。本发明还涉及一种用于预防或治疗细胞坏死和与坏死相关疾病的方法和组合物，包括所述吲哚或吲唑化合物作为活性成分。

  公开号：

  WO2009025478A1

文献信息

• INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS
  申请人：Kim Soon Ha

  公开号：US20100197673A1

  公开（公告）日：2010-08-05

  The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

  本发明涉及吲哚或吲唑化合物，其药学上可接受的盐或异构体，用于预防或治疗细胞坏死和与坏死相关的疾病。本发明还涉及一种用于预防或治疗细胞坏死和与坏死相关疾病的方法和组合物，包括所述吲哚或吲唑化合物作为活性成分。
• [EN] INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS<br/>[FR] COMPOSÉS D'INDOLE ET D'INDAZOLE EN TANT QU'INHIBITEURS DE NÉCROSE CELLULAIRE
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009025478A1

  公开（公告）日：2009-02-26

  The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

  本发明涉及吲哚或吲唑化合物，其药用盐或异构体，可用于预防或治疗细胞坏死和与坏死相关的疾病。本发明还涉及一种用于预防或治疗细胞坏死和与坏死相关疾病的方法和组合物，包括所述吲哚或吲唑化合物作为活性成分。
• INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT
  申请人：Kim Soon Ha

  公开号：US20100291533A1

  公开（公告）日：2010-11-18

  The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

  本发明涉及一种用于保存细胞、组织和器官的组合物，其中包括作为活性成分的式（1）的吲哚和吲唑化合物，或其药用可接受的盐或异构体，对于预防由冷藏、移植手术或移植后再灌注引起的器官、分离的细胞系统或组织的损伤具有有效性；一种保存方法；以及该组合物的制备方法。
• US8349885B2
  申请人：——

  公开号：US8349885B2

  公开（公告）日：2013-01-08
• [EN] INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT<br/>[FR] DÉRIVÉS D'INDOLE ET D'INDOLAZOLE POSSÉDANT UN EFFET DE CONSERVATION DE CELLULES, DE TISSUS ET D'ORGANES
  申请人：——

  公开号：WO2009088192A2

  公开（公告）日：2009-07-16

  본 발명은 기관, 독립된 세포시스템 또는 조직의 저온보관, 이식수술 또는 이식 후 발생하는 재관류에 의한 손상을 예방하는 효과를 지닌 화학식 (1)의 인돌 및 인다졸 화합물, 약제학적으로 허용되는 그의 염 또는 이성체를 유효 성분으로 함유함을 특징으로 하는 세포, 조직 및 장기 보존제 조성물, 보존 방법 및 조성물의 제조방법에 관한 것이다.