2-dodecylpyrrole | 1216-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-dodecylpyrrole
• 英文别名: 2-dodecyl-1H-pyrrole
• CAS: 1216-25-7
• 化学式: C₁₆H₂₉N
• 分子量: 235.413
• InChiKey: GTXIYTMABDZZGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  17
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-dodecylpyrrole 在 盐酸羟胺 、 sodium 、 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 52.0h， 生成 1,4-diaminohexadecane
  参考文献：
  名称：

  1,4-Diaminoalkanes from pyrroles. A new synthetic approach to substituted putrescines

  摘要：

  DOI：

  10.1021/jo00188a021
• 作为产物：
  描述：

  月桂酰氯 在 一水合肼 、 potassium hydroxide 、 锌 作用下， 以 甲苯 、 二乙二醇 为溶剂， 反应 4.0h， 生成 2-dodecylpyrrole
  参考文献：
  名称：

  [EN] PYRROLE DERIVATIVES AS ACC INHIBITORS
  [FR] DÉRIVÉS DE PYRROLE UTILISÉS EN TANT QU'INHIBITEURS D'ACC

  摘要：

  公开了式（I）的新吡咯衍生物；以及它们的制备方法，包括它们的药物组合物以及它们作为乙酰辅酶A羧化酶（ACC）抑制剂在治疗中的用途。

  公开号：

  WO2019115405A1

文献信息

• Metal-Free and Versatile Synthetic Routes to Natural and Synthetic Prodiginines from Boron Dipyrrin
  作者：Jin Li、Qian Zhang、Jian Yin、Changjiang Yu、Kai Cheng、Yun Wei、Erhong Hao、Lijuan Jiao

  DOI：10.1021/acs.orglett.6b02924

  日期：2016.11.4

  possess a number of interesting biological activities. New, concise synthetic routes for the facile preparation of both synthetic and natural prodiginines in good yields have been developed, which use BODIPY functionalization reactions, such as condensation, nucleophilic substitution, and BF2 deprotection. This new metal-free synthetic method opens the door toward a wide variety of C-ring functionalized

  作为细菌生物碱家族的Prodiginines具有许多有趣的生物学活性。已经开发了新的，简明的合成路线，以高收率容易地制备合成的和天然的丙二醛，其使用了BODIPY官能化反应，例如缩合，亲核取代和BF 2脱保护。这种新的无金属合成方法为各种C环功能化的蛋白质打开了大门，其中包括由于其先进的生物活性而无法通过当前的合成方法获得的那些。
• LIPIDIC FURAN, PYRROLE, AND THIOPHENE COMPOUNDS FOR USE IN THE TREATMENT OF ATROPHIC VAGINITIS
  申请人：Avoscience, LLC

  公开号：US20170312246A1

  公开（公告）日：2017-11-02

  Provided herein are lipidic furan, pyrrole, and thiophene compounds, compositions, and methods using such compounds and compositions for the treatment of atrophic vaginitis. Specifically, the invention includes administering an effective amount of a compound of Formula I, I′, or I″, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from atrophic vaginitis.

  本文提供了脂质类呋喃、吡咯和噻吩化合物、组合物以及使用这些化合物和组合物治疗萎缩性阴道炎的方法。具体而言，本发明包括向患有萎缩性阴道炎的受试者投与化合物I、I'或I"的有效量，或者药学上可接受的组合物、盐、同位素类似物、前药或其组合物。
• POLYOLEFIN-BASED RESIN COMPOSITION
  申请人：Sekisui Chemical Co., Ltd.

  公开号：EP2584000A1

  公开（公告）日：2013-04-24

  Provided is a polyolefin-based resin composition capable of obtaining a molded product having a high modulus of elongation and a low coefficient of linear expansion. The polyolefin-based resin composition includes a polyolefin-based resin containing either one or both of an acid-modified polyolefin-based resin and a polyolefin-based resin with a hydroxyl group, and flaked graphite. The flaked graphite is uniformly dispersed in the polyolefin-based resin. As a result, a molded product formed by using the polyolefin-based resin composition has excellent mechanical strength such as a high modulus of elongation, a low coefficient of linear expansion, and high dimensional stability, and can be used for various applications such as a material that is suitable for use as the exterior panels of automobiles or a steel sheet replacement material.

  本发明提供了一种聚烯烃基树脂组合物，可获得具有高伸长模量和低线膨胀系数的模塑产品。该聚烯烃基树脂组合物包括含有酸改性聚烯烃基树脂和带有羟基的聚烯烃基树脂中的一种或两种的聚烯烃基树脂，以及鳞片状石墨。鳞片状石墨均匀地分散在聚烯烃基树脂中。因此，使用该聚烯烃基树脂组合物形成的模塑产品具有优异的机械强度（如高伸长模量、低线膨胀系数和高尺寸稳定性），可用于各种用途，如适合用作汽车外板的材料或钢板替代材料。
• POLYOLEFIN RESIN COMPOSITION AND PROCESS FOR PRODUCING SAME
  申请人：Sekisui Chemical Co., Ltd.

  公开号：EP2583997A1

  公开（公告）日：2013-04-24

  Provided is a polyolefin-based resin composition capable of obtaining a molded product having a high modulus of elongation and a low coefficient of linear expansion. The polyolefin-based resin composition includes a polyolefin-based resin, flaked graphite, and either one or both of a compound with a six-membered ring structure and a compound with a five-membered ring structure. The flaked graphite is uniformly dispersed in the polyolefin-based resin. Thus, a molded product formed using the polyolefin-based resin composition has excellent mechanical strength such as a high modulus of elongation, a low coefficient of linear expansion, and high dimensional stability, and can be used for various applications such as a material that is suitable for use as the exterior panels of automobiles or a sheet metal replacement material.

  本发明提供了一种聚烯烃基树脂组合物，该组合物能够获得具有高伸长模量和低线膨胀系数的模塑产品。聚烯烃基树脂组合物包括聚烯烃基树脂、鳞片状石墨、六元环结构化合物和五元环结构化合物中的一种或两种。鳞片状石墨均匀地分散在聚烯烃基树脂中。因此，使用该聚烯烃基树脂组合物形成的模塑产品具有优异的机械强度，如高伸长模量、低线膨胀系数和高尺寸稳定性，可用于各种用途，如适合用作汽车外板的材料或金属板替代材料。
• Ergonomic assessment garment
  申请人：Google LLC

  公开号：US10366593B2

  公开（公告）日：2019-07-30

  Systems and methods of determining an ergonomic assessment for a user are provided. For instance, sensor data can be received from one or more sensors implemented with an ergonomic assessment garment worn by a user. Corporeal data associated with at least one body segment of the user can be determined based at least in part on the sensor data. The corporeal data is associated with a bend angle associated with the at least one body segment. An ergonomic assessment associated with the user can be determined based at least in part on the corporeal data. The ergonomic assessment can include an indication of one or more ergonomic zones associated with the user, the one or more ergonomic zones being determined based at least in part on the bend angle associated with the at least one body segment.

  本文提供了确定用户人体工学评估的系统和方法。例如，可以从用户穿戴的人体工学评估服装上安装的一个或多个传感器接收传感器数据。与用户至少一个身体部位相关的身体数据可以至少部分根据传感器数据确定。身体数据与至少一个身体部位的弯曲角度相关联。与用户相关的人体工学评估可至少部分地根据身体数据确定。人体工程学评估可包括与用户相关的一个或多个人体工程学区域的指示，一个或多个人体工程学区域至少部分基于与至少一个身体部分相关的弯曲角度确定。