ethyl 6'-amino-3'-methyl-2-oxo-1'-phenyl-4'H-spiro[1-allylindoline-3,4'-pyrano[2,3-c]pyrazole]-5'-carboxylate | 1446353-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 6'-amino-3'-methyl-2-oxo-1'-phenyl-4'H-spiro[1-allylindoline-3,4'-pyrano[2,3-c]pyrazole]-5'-carboxylate
• CAS: 1446353-01-0
• 化学式: C₂₆H₂₄N₄O₄
• 分子量: 456.501
• InChiKey: ANYRBNRJPZAJNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.13
• 重原子数：
  34.0
• 可旋转键数：
  5.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  99.68
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  1-烯丙基-1H-吲哚-2,3-二酮 、 氰乙酸乙酯 、 依达拉奉 在 ammonium cerium (IV) nitrate 作用下， 以 水 为溶剂， 反应 0.33h， 以84%的产率得到ethyl 6'-amino-3'-methyl-2-oxo-1'-phenyl-4'H-spiro[1-allylindoline-3,4'-pyrano[2,3-c]pyrazole]-5'-carboxylate
  参考文献：
  名称：

  Ultrasound promoted green synthesis of spiro[pyrano[2,3-c]pyrazoles] as antioxidant agents

  摘要：

  Ultrasound promoted, cerium ammonium nitrate catalyzed sustainable synthesis of spiro[indoline3,4'-pyrano[2,3-c]pyrazole] derivatives (4a-l) is reported herein. The synthesized compounds were screened for their antioxidant activities as free radical scavenging effect on diphenylpicryl hydrazine (DPPH center dot), 2,2'-azino-bis(3-ethylbenzthiazoline- 6-sulphonic acid) (ABTS(center dot+)) and nitric oxide (NO) radicals. The screened compounds showed potent scavenging activities against DPPH center dot, ABTS(center dot+) and NO radicals. In order to further extend on studies and to obtain a deep insight into structure activity relationship of this class of compounds, we designed N-substitution of indole moiety with the aim to study its antioxidant potential.

  DOI：

  10.1007/s00044-013-0671-8